Zoster Vaccine for Shingles

Recruiting in Palo Alto (17 mi)

Overseen by Ravi Jhaveri, MD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

This goal of this study is to assess the safety and immunogenicity of recombinant zoster virus in young adult solid organ transplant recipients. In this study, participants will receive the recombinant zoster vaccine. They will be monitored for adverse events and tested for antibody and cellular immunity.

Eligibility Criteria

This trial is for young adults who have had a solid organ transplant over a year ago, are on stable immunosuppressive meds for the last 6 months, and can follow up via phone or online. It's not for those with recent vaccine shots, shingles history, current pregnancy, fevers above 39°C, infections needing hospital care or drugs within two weeks before starting.

Inclusion Criteria

I can be contacted via phone, email, or patient portal for study follow-up.

My immunosuppressive medication has not changed in the last 6 months.

I am 18 or older and agree to participate in the study.

Exclusion Criteria

Any condition that, in the opinion of the investigator, may interfere with optimal participation in the study

I haven't had a fever of 39°C or higher or needed antibiotics in the last 14 days.

I am currently taking steroids or other drugs to suppress my immune system.

Participant Groups

The study tests the safety and immune response to the recombinant zoster vaccine in these patients. They'll get vaccinated and then be checked for any negative reactions and their body's defense against shingles will be measured.

Group I: Recombinant Zoster Vaccine Administration and Testing Experimental Treatment 1 Intervention

all participants will receive 2 doses of recombinant zoster vaccine (Shingrix)

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Ann & Robert H. Lurie Children's Hospital Chicago, IL

Who Is Running the Clinical Trial?

Ann & Robert H Lurie Children's Hospital of Chicago Lead Sponsor

Children's Hospital Colorado Collaborator

Children's Hospital Medical Center, Cincinnati Collaborator

References