Anesthesia Types for Cancer Surgery (GA-CARES Trial)

Recruiting in Palo Alto (17 mi)

+4 other locations

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: Stony Brook University

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?This trial is testing two ways to keep patients asleep during cancer surgery: one using an IV drug called propofol and the other using inhaled gases. It aims to see which method is better at reducing the risk of death from any cause. Propofol is a widely used intravenous anesthetic known for its potential effects on cancer outcomes.

Eligibility Criteria

The GA-CARES trial is for adult cancer patients undergoing specific surgeries like lung, esophagus, bladder, pancreas removal or certain chemo procedures. It's not for those under 18, with a very short life expectancy, severe health issues (ASA Class 5), egg/soy allergies, or sensitivity to anesthesia.

Inclusion Criteria

I am scheduled for a major cancer surgery, such as lung, esophagus, bladder, pancreas, liver, stomach removal or specific chemotherapy.

Exclusion Criteria

I am under 18 years old.

Participant Groups

This study compares two ways of keeping people asleep during cancer surgery: using propofol through an IV or inhaling agents like sevoflurane. The goal is to see which method affects survival rates after surgery.

2Treatment groups

Experimental Treatment

Group I: Volatile agentExperimental Treatment1 Intervention

Maintenance of general anesthesia with volatile agent (sevoflurane, desflurane, or isoflurane)

Group II: Propofol infusionExperimental Treatment1 Intervention

Maintenance of general anesthesia with propofol infusion