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Neurolytic Agent

Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain

Phase 4
Waitlist Available
Led By Paul So, MD
Research Sponsored by Kessler Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 1 month, 3 months, 6 months
Awards & highlights
Drug Has Already Been Approved
Pivotal Trial

Summary

This trial is testing a new treatment for people with severe knee pain from osteoarthritis who haven't found relief from other treatments. The treatment involves injecting a chemical to deactivate certain nerves in the knee, which can help reduce pain and improve movement. Researchers believe this method could be an effective and less expensive alternative to other procedures.

Eligible Conditions
  • Osteoarthritis
  • Chronic Knee Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 1 month, 3 months, 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 1 month, 3 months, 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in NRS pain score from baseline
Secondary study objectives
Change in WOMAC score from baseline

Awards & Highlights

Drug Has Already Been Approved
The FDA has already approved this drug, and is just seeking more data.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment GroupExperimental Treatment1 Intervention
6% aqueous phenol, 1.5 mL per target site
Group II: Placebo GroupPlacebo Group1 Intervention
Isotonic saline, 1.5 mL per target site

Find a Location

Who is running the clinical trial?

Kessler FoundationLead Sponsor
183 Previous Clinical Trials
11,103 Total Patients Enrolled
2 Trials studying Osteoarthritis
30 Patients Enrolled for Osteoarthritis
Paul So, MDPrincipal InvestigatorKessler Institute for Rehabilitation

Media Library

Osteoarthritis Clinical Trial 2023: 6% aqueous phenol Highlights & Side Effects. Trial Name: NCT04989660 — Phase 4
Osteoarthritis Patient Testimony for trial: Trial Name: NCT04989660 — Phase 4
~7 spots leftby Dec 2025
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