Platelet Rich Fibrin for Tooth Abscess
(EMS Trial)

Recruiting in Palo Alto (17 mi)

Overseen byMark Schachman, DMD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: Mark Schachman

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?Current literature on platelet rich fibrin (PRF) use in apicoectomies, also known as endodontic microsurgery, is sparse. PRF use in oral surgery or periodontal surgery has been more thoroughly researched. Whether it is able to reduce post-op pain or if it improves success rate in endodontic microsurgery is not well known. It is also not well known if it will be able to increase the rate of healing. This study will evaluate the success of endodontic microsurgery with and without PRF.

Eligibility Criteria

This trial is for individuals with conditions like tooth abscess, apical periodontitis, or general periodontitis. Specific eligibility criteria are not provided, so it's best to contact the study organizers for detailed requirements.

Inclusion Criteria

I have front teeth or premolars that had root canal treatment fail with a visible issue on an X-ray.

Exclusion Criteria

My teeth cannot be fixed.

Pregnant

Smoker

+3 more

Participant Groups

The trial is testing the use of Platelet Rich Fibrin (PRF) in endodontic microsurgery to see if it reduces post-op pain, improves success rates and increases healing speed compared to standard treatment without PRF.

2Treatment groups

Experimental Treatment

Active Control

Group I: Microsurgery with Platelet Rich FibrinExperimental Treatment1 Intervention

Patents will have a blood draw completed so that PRF can be made. Endodontic microsurgery will then be completed. Prior to closing the flap, PRF will be placed in the osteotomy.

Group II: Microsurgery AloneActive Control1 Intervention

Endodontic microsurgery will be completed without PRF. The osteotomy will remain empty as per standard procedure.