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Corticosteroid

Prednisone for Chronic Sinusitis

Phase 4
Waitlist Available
Led By Bruce Tan, MD
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4-6 weeks and 3 months after initiation of treatment
Awards & highlights

Summary

The purpose of this study is to determine the most effective route to administer steroids to patients with chronic sinusitis, specifically a type of chronic sinusitis not associated with nasal polyps (CRSsNP). The investigators would like to better understand whether orally administered steroids results in superior results when compared with nasally sprayed steroids. The investigators propose to test the hypothesis that for patients with radiographically proven CRSsNP, routine medical therapy consisting of a short course of systemic corticosteroids is superior to topical corticosteroids for relieving inflammation and the symptoms of CRS.

Eligible Conditions
  • Chronic Sinusitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4-6 weeks and 3 months after initiation of treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4-6 weeks and 3 months after initiation of treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
SNOT-22 Questionnaire
Secondary outcome measures
Lund-McKay Score From CT Scan
Medication Side-effect and Compliance Inventory
Taskforce Symptom Inventory

Trial Design

2Treatment groups
Active Control
Group I: PrednisoneActive Control1 Intervention
Oral steroid medication
Group II: Topical MometasoneActive Control1 Intervention
Topical steroid medication

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,608 Previous Clinical Trials
927,308 Total Patients Enrolled
3 Trials studying Chronic Sinusitis
226 Patients Enrolled for Chronic Sinusitis
Bruce Tan, MDPrincipal InvestigatorNorthwestern University
1 Previous Clinical Trials
42 Total Patients Enrolled
~1 spots leftby Jul 2025
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