Epigenetic Regulation of Adipose Tissue Distribution in Obesity
(Eiffel 2 Trial)

Recruiting in Palo Alto (17 mi)

Overseen BySteven R Smith, MD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Translational Research Institute for Metabolism and Diabetes, Florida

No Placebo Group

Trial Summary

What is the purpose of this trial?The purpose of this study is to collect data to help researchers better understand the different ways that women or men store fat (apple shape versus pear shape).

Eligibility Criteria

This trial is for men and women aged 18-45 with a BMI of 23-35, stable weight in the last three months, non-smokers, not pregnant or postpartum beyond nine months. Excluded are those with serious health conditions like uncontrolled hypertension, kidney/liver disease, recent heart attacks or cancer, untreated thyroid issues or certain mental illnesses.

Inclusion Criteria

Age 18-45 years inclusive

HbA1C <6.0%

Weight stable (± 3 kg) during the 3 months prior to enrollment

+3 more

Exclusion Criteria

Postmenopausal women

You have received an organ transplant in the past.

Creatinine > 2x upper limit of laboratory reference range, or known diagnosis of kidney disease

+18 more

Participant Groups

Researchers are studying how adults store fat differently by using tests like FSIGTT/RMR to measure insulin sensitivity and metabolism; DEXA/MRI/MRS scans to visualize body composition; and adipose tissue biopsies to examine fat distribution at a cellular level.

3Treatment groups

Active Control

Group I: Group A- Women- Healthy 'pears'Active Control3 Interventions

This group will consist of healthy women with a BMI between 23 and 35 kg/m2 as a waist-to-hip ratio of 0.78 or less.

Group II: Group B- Women- Healthy 'apples'Active Control3 Interventions

The group will consist of healthy women with a BMI between 23 and 35 kg/m2 as a waist-to-hip ratio of 0.85 or more.

Group III: Group C- Men- Healthy 'apples'Active Control3 Interventions

The group will consist of men with a BMI between 23 and 35 kg/m2.