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Hyperpolarized Xenon MRI for Lung Function Assessment in Healthy Subjects

N/A
Recruiting
Led By Grace E Parraga, PhD
Research Sponsored by Western University, Canada
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Able to perform a breath hold for up to 16 sec
Be older than 18 years old
Must not have
Subject has a daytime room air oxygen saturation <90% while lying supine
Patient is unable to perform spirometry or plethysmography maneuvers
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing if a new MRI technique can help assess lung function.

Who is the study for?
This trial is for healthy adults aged 18-85 who can hold their breath up to 16 seconds, have a BMI of 18-40, and a minimal smoking history. They must be in stable health and able to perform certain lung function tests. People with mental incapacitation, severe claustrophobia, implanted devices or metal in their body that cannot be removed are excluded.
What is being tested?
The study is testing the use of hyperpolarized Xenon MRI technology on healthy subjects. It aims to develop tools for assessing image quality and consistency across repeated scans while also evaluating participants' lung function.
What are the potential side effects?
Since this trial involves imaging technology rather than medication, side effects are minimal but may include discomfort from holding one's breath during the scan or feelings of claustrophobia inside the MRI machine.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I can hold my breath for up to 16 seconds.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
My oxygen levels drop below 90% when I'm lying down without extra oxygen.
Select...
I cannot perform certain lung function tests.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Dissolved Phase Spectroscopy Measurements

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Healthy VolunteersExperimental Treatment1 Intervention
Healthy volunteers will undergo pulmonary function tests, hyperpolarized Xenon MRI at each visit.

Find a Location

Who is running the clinical trial?

London Health Sciences CentreOTHER
148 Previous Clinical Trials
57,184 Total Patients Enrolled
Western University, CanadaLead Sponsor
254 Previous Clinical Trials
59,236 Total Patients Enrolled
Grace E Parraga, PhDPrincipal InvestigatorRobarts Research Institute, The University of Western Ontario
14 Previous Clinical Trials
1,314 Total Patients Enrolled

Media Library

Healthy Volunteers Clinical Trial Eligibility Overview. Trial Name: NCT02484885 — N/A
Healthy Subjects Research Study Groups: Healthy Volunteers
Healthy Subjects Clinical Trial 2023: Healthy Volunteers Highlights & Side Effects. Trial Name: NCT02484885 — N/A
Healthy Volunteers 2023 Treatment Timeline for Medical Study. Trial Name: NCT02484885 — N/A
~2 spots leftby Aug 2025
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