Barley Lysine Availability for Healthy Subjects

Recruiting in Palo Alto (17 mi)

Overseen byGlenda Courtney-Martin, PhD

Age: 18 - 65

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: The Hospital for Sick Children

No Placebo Group

Trial Summary

What is the purpose of this trial?

Protein is the key determinant of growth and bodily functions. The quality of food proteins depend on their amino acid content and the amount of amino acids used by the body to make proteins. Globally Cereal Grains (CG) provide 50% of the calories and protein in the diet and exceed 80% in poorer developing countries. Barley is an important cereal grain in the diet. The protein in barley is low in the essential amino acid lysine. Hence barley protein is of low quality. Low lysine affects protein synthesis in the body. Cooking methods also affect the lysine available from foods to the body. It is important to assess the effect of different cooking methods on the lysine availability of barley.

Eligibility Criteria

This trial is for healthy young men aged 18-40 with stable body weight, not on medication affecting protein metabolism like steroids. They must have no clinical conditions such as diabetes that affect protein or amino acid metabolism and no recent significant weight changes.

Inclusion Criteria

I am healthy and do not have conditions like diabetes that affect protein metabolism.

I am not taking steroids or any drugs that affect protein in my body.

Stable Body Weight (±0 to 5lb weight gain or loss in the last 3 months)

See 1 more

Exclusion Criteria

You cannot eat the food provided in the study due to allergies or other reasons.

Recent history of weight loss within the last 3 months or on a weight reducing diet

I am not willing or able to follow the study's diet plan.

Treatment Details

Interventions

Barley (Amino Acid Supplement)

Trial OverviewThe study examines how the body uses lysine from barley, focusing on the impact of cooking methods on its availability. Barley's low lysine content affects protein synthesis, which is crucial for growth and bodily functions.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Meabolic Availabiliy of BarleyExperimental Treatment1 Intervention

Healthy adult men