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Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients (IGNITE Trial)
N/A
Waitlist Available
Led By Robert L Owens, MD
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 hours
Awards & highlights
No Placebo-Only Group
Summary
This trial will study the effects of different ventilator settings on patients with end-stage cardiac or respiratory failure who are receiving Extracorporeal Membrane Oxygenation (ECMO) therapy. The goal is to determine the best ventilator settings to minimize Ventilator Induced Lung Injury (VILI) and reduce the risk of multi-organ failure.
Eligible Conditions
- Heart Failure
- Difficult Weaning
- Breathing Failure
- Critical Illness
- Acute Respiratory Distress Syndrome
- Extracorporeal Membrane Oxygenation
- Kidney Failure
- Lung Disease
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 hours
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 hours
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in plasma IL-6 level from baseline to low driving pressure ventilation
Secondary study objectives
Change in plasma sRAGE from baseline to low driving pressure ventilation
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Low Driving Pressure ProtocolExperimental Treatment1 Intervention
The patients ventilator driving pressure will be decreased (as tolerated by the patient) for 2 hours while on extracorporeal membrane oxygenation (ECMO) support.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ventilator
2011
N/A
~510
Find a Location
Who is running the clinical trial?
University of California, San DiegoLead Sponsor
1,189 Previous Clinical Trials
1,587,661 Total Patients Enrolled
Robert L Owens, MDPrincipal InvestigatorUCSD
2 Previous Clinical Trials
54 Total Patients Enrolled