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Vitamin Supplement
Vitamin C for Acute Pain (Vicamed Trial)
N/A
Waitlist Available
Led By Raoul Daoust, MD MSc
Research Sponsored by Hopital du Sacre-Coeur de Montreal
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 days
Summary
"This trial aims to determine if vitamin C can reduce pain intensity in patients with acute musculoskeletal pain over a seven-day period following an emergency department visit. Participants will either receive vitamin C or a placebo
Who is the study for?
This trial is for adults over 18 who visited the emergency department with acute musculoskeletal pain, like a fracture or sprain, that's lasted less than 48 hours. They should have a pain level of at least 4 out of 10 and be prescribed NSAIDs without opioids. It's not suitable for those who can't safely take vitamin C or acetaminophen.
What is being tested?
The study tests if vitamin C can help reduce pain after an ED visit for acute musculoskeletal issues. Participants will either get vitamin C or a placebo twice daily for seven days, along with regular doses of acetaminophen. Naproxen is provided as backup if needed.
What are the potential side effects?
Vitamin C is generally safe but may cause minor side effects like stomach upset in some people. Acetaminophen could lead to liver damage when used in large amounts or long-term, and naproxen may cause gastrointestinal issues.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ seven days
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~seven days
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Daily pain intensity
Secondary study objectives
Adverse events
NSAIDs consumption
New analgesic prescriptions
+6 moreTrial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Acetaminophen and Vitamin C with Naproxen rescueExperimental Treatment1 Intervention
900 mg vitamin C taken orally twice a day Extended-release acetaminophen 650 mg two pills every eight hours regularly
Naproxen 500 mg as a rescue medication
Group II: Acetaminophen and Placebo with Naproxen rescuePlacebo Group1 Intervention
Placebo taken orally twice a day Extended-release acetaminophen 650 mg two pills every eight hours regularly
Naproxen 500 mg as a rescue medication
Find a Location
Who is running the clinical trial?
Hopital de l'Enfant-JesusOTHER
16 Previous Clinical Trials
5,276 Total Patients Enrolled
1 Trials studying Acute Pain
2,240 Patients Enrolled for Acute Pain
The Ottawa HospitalOTHER
94 Previous Clinical Trials
63,210 Total Patients Enrolled
Hopital du Sacre-Coeur de MontrealLead Sponsor
51 Previous Clinical Trials
11,602 Total Patients Enrolled
2 Trials studying Acute Pain
3,001 Patients Enrolled for Acute Pain
Raoul Daoust, MD MScPrincipal InvestigatorUniversité de Montréal
3 Previous Clinical Trials
3,465 Total Patients Enrolled
2 Trials studying Acute Pain
3,001 Patients Enrolled for Acute Pain