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Local Anesthetic

Continuous Nerve Block for Post-Knee Replacement Pain

N/A
Recruiting
Led By Naveed Siddiqui, MD, MSc
Research Sponsored by University of Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients older than 21 years of age
American Society of Anesthesiologists (ASA) physical status I-III
Must not have
Patients with contraindications to the insertion of an epidural or adductor canal catheter (severe anatomic abnormalities or history of previous surgery at the site of catheter placement)
Chronic opioid use of morphine 30mg equivalent per day for last 2 consecutive weeks
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 90

Summary

This trial aims to see if using a continuous nerve block during total knee arthroplasty can improve outcomes and pain management compared to single shot nerve blocks.

Who is the study for?
This trial is for patients over 21 years old who are having knee replacement surgery as outpatients and have a moderate risk of complications (ASA I-III). They should not be dependent on alcohol or drugs, understand the treatment process, and cannot be using strong painkillers regularly. People with allergies to study meds, blood clotting issues, low platelet counts, or problems where the catheter goes can't join.
What is being tested?
The study tests if continuous adductor canal block (CACB), which involves infusing pain medication through a tube near nerves in the thigh, provides better pain control and recovery after outpatient knee surgery compared to a sham procedure without real medicine (ShACB).
What are the potential side effects?
Potential side effects may include discomfort at the catheter site, infection risk from the tube placement, possible nerve damage around the thigh area where medication is infused, and typical reactions to local anesthetics like numbness or weakness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am older than 21 years.
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My overall health is good to moderately impaired.
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I am having knee replacement surgery on one knee as an outpatient.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I cannot have an epidural or catheter due to severe body structure issues or past surgery.
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I have been using opioids equivalent to 30mg of morphine daily for the past 2 weeks.
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I was admitted to the hospital due to complications after surgery.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 90
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 90 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Quality of Recovery 15 score (QoR-15)
Secondary study objectives
Opioid usage
Pain scores

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Continuous adductor canal block (CACB)Experimental Treatment1 Intervention
Will receive an infusion of 0.2% ropivacaine 5mL/h through adductor canal catheter.
Group II: Sham continuous adductor canal block (ShACB).Placebo Group1 Intervention
Will receive an infusion of NaCl 0.9% 5mL/h through adductor canal catheter.

Find a Location

Who is running the clinical trial?

University of TorontoLead Sponsor
719 Previous Clinical Trials
1,042,496 Total Patients Enrolled
MOUNT SINAI HOSPITALOTHER
42 Previous Clinical Trials
16,924 Total Patients Enrolled
Naveed Siddiqui, MD, MScPrincipal InvestigatorUniversity of Toronto
1 Previous Clinical Trials
223 Total Patients Enrolled
~27 spots leftby Nov 2025
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