Ibuprofen for Pain After Wisdom Tooth Extraction
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines the effectiveness of ibuprofen for dental pain following wisdom teeth removal. Some individuals require additional pain relief with opioids, and the study aims to determine the reasons. This could help doctors avoid prescribing opioids when ibuprofen alone suffices. Ideal participants are those undergoing wisdom tooth removal, experiencing moderate pain post-surgery, and having no major health issues.
As a Phase 2 trial, this research measures ibuprofen's effectiveness in an initial, smaller group, offering participants the opportunity to contribute to important findings that could enhance pain management strategies.
Do I have to stop taking my current medications for the trial?
The trial requires you to stop taking certain medications, like pain relievers and sedatives, 24 hours before the surgery. However, hormonal contraceptives, hormone replacement therapy, and thyroid replacement hormones are allowed. Other stable medications may be allowed if the investigator agrees.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that taking ibuprofen and acetaminophen together is safe and effective for pain relief after dental surgery, such as wisdom teeth removal. Studies have found that this combination manages pain better than some opioid treatments, particularly in the first few days post-surgery. Patients report experiencing less pain and improved sleep with these medications.
Both ibuprofen and acetaminophen are commonly used and trusted for dental pain. A recent study involving over 1,800 patients found this combination effectively reduced pain and improved sleep. While all medications can have side effects, this combination maintains a strong safety record for those recovering from dental procedures.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to understand why some people need extra pain relief after wisdom tooth removal, even when taking ibuprofen and acetaminophen. This trial is unique as it explores how different patients respond to the same pain medication combination, potentially identifying why some require additional opioids while others don't. By uncovering these differences, the trial could lead to more personalized pain management strategies, reducing the need for opioids and enhancing patient comfort.
What evidence suggests that this trial's treatments could be effective for post-surgical dental pain?
Research has shown that taking ibuprofen with acetaminophen effectively reduces pain after dental surgeries like wisdom tooth removal. One study found that a single dose of 400 mg of ibuprofen eased pain after these procedures. Another large study with over 1,800 participants demonstrated that this combination relieved pain better than opioids, which are strong painkillers. Additionally, using these two over-the-counter (OTC) medications together usually causes fewer side effects than using opioids. In this trial, some participants, labeled as "Complete Responders," will manage their pain with just ibuprofen and acetaminophen, while others, labeled as "Partial Responders," may require supplemental opioids. Overall, this suggests that most patients can manage dental pain effectively without needing stronger medications.26789
Who Is on the Research Team?
Katherine N Theken, PharmD, PhD
Principal Investigator
University of Pennsylvania
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive ibuprofen 400 mg + acetaminophen 500 mg every 4 hours, with supplemental opioids as needed, following third molar extraction
Follow-up
Participants are monitored for pain intensity, supplemental opioid use, and various biological assessments
What Are the Treatments Tested in This Trial?
Interventions
- Ibuprofen
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Patients who require supplemental opioids (oxycodone 5 mg), in addition to ibuprofen 400 mg + acetaminophen 500 mg every 4 hours, for pain relief following third molar extraction
Patients who do not require supplemental opioids, in addition to ibuprofen 400 mg + acetaminophen 500 mg every 4 hours, for pain relief following third molar extraction
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pennsylvania
Lead Sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
Collaborator
Citations
Pain Relief with Combination Acetaminophen/Codeine or ...
Conclusions: Our data indicate that single dose of ibuprofen (400 mg) is an effective pain reducer for post third molar extraction pain.
2.
rutgershealth.org
rutgershealth.org/news/non-opioid-pain-relievers-beat-opioids-after-dental-surgeryNon-Opioid Pain Relievers Beat Opioids After Dental Surgery
The trial in more than 1,800 patients found that those given a combination of ibuprofen and acetaminophen experienced less pain, better sleep ...
3.
sciencedirect.com
sciencedirect.com/science/article/abs/pii/S0002817714605092?utm_source=chatgpt.comCombining ibuprofen and acetaminophen for acute pain ...
The results of the quantitative systematic reviews indicated that the ibuprofen-APAP combination may be a more effective analgesic, with fewer untoward effects, ...
4.
urmc.rochester.edu
urmc.rochester.edu/news/story/new-study-finds-otc-pain-relievers-outperform-opioidsNew Study Finds OTC Pain Relievers Outperform Opioids
A combination of over-the-counter pain relievers is more effective than opioids in managing pain after wisdom tooth extractions.
What's the Best Pain Relief after a Tooth Extraction?
Ibuprofen taken in combination with acetaminophen is the most effective way to ease dental pain. In fact, in most cases, the combination of the two is more ...
Ibuprofen and/or paracetamol (acetaminophen) for pain relief ...
Both paracetamol and ibuprofen are commonly used analgesics for the relief of pain following the surgical removal of lower wisdom teeth (third molars).
Pain control following impacted mandibular third molar ...
The findings of this study show that the combination of Paracetamol and Ibuprofen are well-tolerated and effective option for post operative pain after ...
Nonopioid vs opioid analgesics after impacted third-molar ...
The ibuprofen and acetaminophen combination managed pain better for the first 2 days and led to greater satisfaction over the entire postoperative period.
9.
news-medical.net
news-medical.net/news/20250106/Non-opioid-pain-relief-proven-more-effective-after-wisdom-teeth-removal.aspxNon-opioid pain relief proven more effective after wisdom ...
The trial in more than 1,800 patients found that those given a combination of ibuprofen and acetaminophen experienced less pain, better sleep ...
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