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Fatty Acid Diets for Aging

N/A

Recruiting

Led By Julie Dumas, Ph.D.

Research Sponsored by University of Vermont

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

"Healthy" (body mass index (BMI) of 20-40 kg/m2)

Men and women age range 65-75 years

Must not have

Type 2 Diabetes if receiving any other therapy than metformin

Hormone replacement therapy, past 3 months

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after 7 days of each diet

Awards & highlights

No Placebo-Only Group

Summary

This trial will study how different types of fats in the diet affect brain functioning in healthy adults aged 65-75 years. Participants will be given two different diets, one with a high ratio of pal

Who is the study for?

This trial is for healthy older adults aged 65-75 who want to participate in a study on how different fats in the diet affect brain function. Participants will follow strict diets provided by the research team and be closely monitored.

What is being tested?

The study tests two diets: one high in palmitic acid, like a typical North American diet, and another high in oleic acid, similar to the Mediterranean Diet. Each participant tries both for one week with a low-fat control diet before each test period.

What are the potential side effects?

Since this trial involves dietary changes rather than medication, side effects may include digestive discomfort or changes in energy levels as the body adjusts to new types of fat intake.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My BMI is between 20 and 40.

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I am between 65 and 75 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have Type 2 Diabetes and am treated with drugs other than metformin.

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I have been on hormone replacement therapy in the last 3 months.

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I have a medical condition that could affect my thinking or cause inflammation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after 7 days of each diet

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after 7 days of each diet

This trial's timeline: 3 weeks for screening, Varies for treatment, and after 7 days of each diet for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Working Memory Brain Activation

Working Memory Brain Functional Connectivity

Working Memory Performance

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: High Palmitic Acid Diet (HPA)Experimental Treatment1 Intervention

Participants will ingest the HPA diet for one week. The saturated fatty acid will be high in palmitic acid which is the most prevalent saturated fatty acid in the American diet. The HPA diet will be proceeded by a one week controlled diet were the fat content is balanced between monounsaturated and saturated fatty acids.

Group II: High Oleic Acid/Low Palmitic Acid Diet (HOA)Experimental Treatment1 Intervention

Participants will ingest the HOA diet for one week. The monounsaturated fatty acid will be high in oleic acid which is the most prevalent monounsaturated fatty acid in the Mediterranean diet. The HOA diet will be proceeded by a one week controlled diet were the fat content is balanced between monounsaturated and saturated fatty acids.

0 / 5Eligibility criteria met