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Protein

Protein Intake for Aging Muscle Growth

N/A

Waitlist Available

Led By Stuart Phillips, PhD

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be a male or female, between the ages of 65 - 80 years (inclusive)

Be older than 65 years old

Must not have

Any cachexia-related condition (e.g., relating to cancer, tuberculosis or human immunodeficiency virus infection and acquired immune deficiency syndrome) or any genetic muscle diseases or disorders

Personal or family history of a clotting disorder or deep vein thrombosis

Timeline

Screening 3 weeks

Treatment Varies

Follow Up one day in response to 3 main meals (twice during the study - 1 day ingesting vegan meals and another day ingesting lacto-vegetarian meals)

Awards & highlights

No Placebo-Only Group

Summary

This trial is investigating how different amounts and types of protein affect muscle growth in older adults.

Who is the study for?

This trial is for men and women aged 65-80, in good health with a BMI of 20-35. Participants must be non-smokers, able to consent, and not use walking aids or have certain medical conditions like recent cancer (except some types), clotting disorders, severe illnesses affecting the study's integrity or taking specific supplements or steroids.

What is being tested?

The study investigates how different amounts and types of protein affect muscle growth in older adults. It compares the effects of a plant-based diet versus a Lacto-vegetarian diet on maintaining muscle mass as people age.

What are the potential side effects?

Since this trial involves dietary changes rather than medication, side effects may include digestive discomfort due to new food types or quantities. Specific side effects will depend on individual reactions to dietary adjustments.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 65 and 80 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a condition causing significant weight loss, muscle loss, or weakness.

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I or my family have a history of blood clots.

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I use a cane or walker to help me walk.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ one day in response to 3 main meals (twice during the study - 1 day ingesting vegan meals and another day ingesting lacto-vegetarian meals)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~one day in response to 3 main meals (twice during the study - 1 day ingesting vegan meals and another day ingesting lacto-vegetarian meals)

This trial's timeline: 3 weeks for screening, Varies for treatment, and one day in response to 3 main meals (twice during the study - 1 day ingesting vegan meals and another day ingesting lacto-vegetarian meals) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Dynamic proteome profiling (synthesis and breakdown)

Integrated muscle protein synthesis

Whole-body protein balance

Secondary study objectives

Cell signaling pathways regulating protein synthesis in skeletal muscle

Daily plasma amino acid concentration

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: RDA Lacto-Vegetarian/VeganExperimental Treatment1 Intervention

Subjects will receive diets containing the RDA for protein from Lacto-vegetarian and Vegan sources in different periods during the protocol.

Group II: Higher than RDA Lacto-Vegetarian/VeganExperimental Treatment1 Intervention

Subjects will receive diets containing more than the RDA for protein from Lacto-vegetarian and Vegan sources in different periods during the protocol.

0 / 4Eligibility criteria met