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nasal mask for Mechanical Ventilation Complication

N/A
Waitlist Available
Led By Hovig V Chitilian, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up in 30 minutes after the induction of general anesthesia
Awards & highlights

Summary

Recently, the investigators demonstrated that nasal route ventilation is superior to the nasal-oral combined ventilation in the absence of jaw thrust and chin up maneuvers. The investigators hypothesize nasal mask ventilation may reduce the incidence of difficult mask ventilation during the induction of general anesthesia by: 1) producing a better seal than full face mask, and 2)establishing a greater airway patency and more effectively ventilate than full face mask ventilation. The investigators intend to test this hypothesis on adult patients during the induction of general anesthesia in the absence of muscle relaxation.

Eligible Conditions
  • Mechanical Ventilation Complication
  • Airway Obstruction

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~in 30 minutes after the induction of general anesthesia
This trial's timeline: 3 weeks for screening, Varies for treatment, and in 30 minutes after the induction of general anesthesia for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Tidal volume
Secondary outcome measures
Carbon dioxide removal

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: nasal maskExperimental Treatment2 Interventions
when the patient is apneic after the injection of anesthetics in the operating room, a nasal mask will be applied with positive pressure ventilation for 1 min. Then the nasal mask will be replaced with a full face mask for 1 min. Subsequently, the face mask will be replaced with the nasal mask.
Group II: full face maskActive Control2 Interventions
when the patient is apneic after the injection of anesthetics in the operating room, a full face mask will be applied with positive pressure ventilation for 1 min. Then the full face mask will be replaced with a nasal mask for 1 min. Subsequently, the nasal mask will be replaced with the full face mask.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
full face mask
2012
N/A
~60
nasal mask
2012
N/A
~140

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,993 Previous Clinical Trials
13,230,669 Total Patients Enrolled
1 Trials studying Mechanical Ventilation Complication
50 Patients Enrolled for Mechanical Ventilation Complication
Hovig V Chitilian, MDPrincipal InvestigatorMassachusetts General Hospital
Yandong Jiang, MD, PhDPrincipal InvestigatorMassachusetts General Hospital
10 Previous Clinical Trials
305 Total Patients Enrolled
~4 spots leftby Sep 2025