← Back to Search

Radiation

Adaptive Radiotherapy for Brain Tumor

N/A

Recruiting

Led By Tony J. Wang, MD

Research Sponsored by Columbia University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Plan to receive 60 Gy in 30 fractions of radiotherapy and not hypofractionated radiotherapy and not hypofractionated radiotherapy including 40 Gy in 15 fractions

Histopathologically proven diagnosis of glioblastoma, anaplastic astrocytoma, or anaplastic oligodendroglioma

Must not have

Prior malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 2 years

Prior therapy for tumor except for biopsy or resection, including prior radiotherapy to the brain

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

No Placebo-Only Group

Summary

This trial investigates if MRI scans during radiation can improve treatment of high-grade brain tumors.

Who is the study for?

This trial is for adults over 18 with high-grade gliomas like glioblastoma, who haven't had previous tumor treatments except biopsy or resection. They must have a Karnofsky performance status of 70+ and plan to receive standard radiotherapy. Pregnant women can't participate.

What is being tested?

The study tests if extra MRI scans during the weekly radiation treatment can improve outcomes for patients with aggressive brain tumors. It aims to adapt radiotherapy more precisely to the changes in the tumor's size and shape.

What are the potential side effects?

While not explicitly listed, side effects may include typical reactions from regular MRIs and radiotherapy such as headaches, nausea, fatigue, skin irritation at the treatment site, and potential short-term memory issues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am scheduled for a specific radiotherapy plan, not a shortened course.

Select...

My diagnosis is a type of aggressive brain tumor.

Select...

I am able to care for myself but cannot do normal activities without help.

Select...

I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have been cancer-free for at least 2 years, except for non-melanoma skin cancer.

Select...

I have only had a biopsy or surgery for my tumor, no other treatments.

Select...

My cancer has spread outside the brain.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Prediction of progression of disease in patients with high-grade glioma.

Secondary study objectives

Estimate the progression-free and overall survival in patient with high-grade glioma.

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Adaptive RadiotherapyExperimental Treatment1 Intervention

Subjects will receive radiotherapy per standard of care over 30-33 once-daily fractions in addition to 7 brain MRIs each in every week of treatment. Subjects receiving hypofractionated radiotherapy will receive radiotherapy per standard of care over 15 once-daily fractions in addition to 4 brain MRIs each in every week of treatment.

0 / 7Eligibility criteria met