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Behavioral Intervention

Affect Treatment for Depression and Anxiety

N/A
Waitlist Available
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Willingness to refrain from starting other psychosocial or pharmacological treatments until study completion
Be older than 18 years old
Must not have
Current active suicidal ideation
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition)
Awards & highlights

Summary

This trial aims to see if patients who do not improve with positive therapy could benefit from switching to a different type of therapy that focuses on reducing sensitivity to threats. Participants will undergo various tests and assessments over

Who is the study for?
This trial is for individuals experiencing anxiety and depression who haven't improved with initial positive affect treatment. Participants will undergo lab tests, psychiatric assessments, and questionnaires over a 5-month period.
What is being tested?
The study is testing if switching from Positive Affect Treatment (PAT) to Negative Affect Treatment improves outcomes for those not responding well to PAT alone in treating anxiety and depression.
What are the potential side effects?
Potential side effects are not specified but may include discomfort or emotional distress due to the nature of psychological treatments and the conditions being addressed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I agree not to start any new mental health or drug treatments until the study ends.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am currently experiencing thoughts of harming myself.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Depression Anxiety and Stress Scale (DASS-21)
Positive and Negative Affect Schedule Expanded (PANAS-X) (General Dimensions Scales)
Secondary study objectives
Beck Depression Inventory (BDI-9)
Behavioral Inhibition/Behavioral Activation (reward drive subscale) (BAS-RD)
Dimensional Anhedonia Rating Scale (DARS)
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Positive Affect TreatmentExperimental Treatment1 Intervention
8 sessions of psychotherapy designed to augment reward anticipation, reward attainment, and reward learning.
Group II: Positive Affect Treatment and Negative Affect TreatmentActive Control1 Intervention
8 sessions of psychotherapy. 3-5 sessions of psychotherapy designed to augment reward anticipation, reward attainment, and reward learning. Remaining sessions of psychotherapy designed to decrease threat avoidance, threat appraisal and arousal.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Positive Affect Treatment
2019
N/A
~110

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,554 Previous Clinical Trials
10,264,014 Total Patients Enrolled
104 Trials studying Depression
48,926 Patients Enrolled for Depression
Southern Methodist UniversityOTHER
36 Previous Clinical Trials
5,896 Total Patients Enrolled
6 Trials studying Depression
981 Patients Enrolled for Depression
~50 spots leftby Mar 2025
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