Behavioral Intervention

Affect Treatment for Depression and Anxiety

Los Angeles, CA

N/A

Waitlist Available

Research Sponsored by University of California, Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Willingness to refrain from starting other psychosocial or pharmacological treatments until study completion

Be older than 18 years old

Must not have

Current active suicidal ideation

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition)

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to see if patients who do not improve with positive therapy could benefit from switching to a different type of therapy that focuses on reducing sensitivity to threats. Participants will undergo various tests and assessments over

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Who is the study for?

This trial is for individuals experiencing anxiety and depression who haven't improved with initial positive affect treatment. Participants will undergo lab tests, psychiatric assessments, and questionnaires over a 5-month period.Check my eligibility

What is being tested?

The study is testing if switching from Positive Affect Treatment (PAT) to Negative Affect Treatment improves outcomes for those not responding well to PAT alone in treating anxiety and depression.See study design

What are the potential side effects?

Potential side effects are not specified but may include discomfort or emotional distress due to the nature of psychological treatments and the conditions being addressed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I agree not to start any new mental health or drug treatments until the study ends.

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Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am currently experiencing thoughts of harming myself.

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Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Depression Anxiety and Stress Scale (DASS-21)

Positive and Negative Affect Schedule Expanded (PANAS-X) (General Dimensions Scales)

Secondary study objectives

Beck Depression Inventory (BDI-9)

Behavioral Inhibition/Behavioral Activation (reward drive subscale) (BAS-RD)

Dimensional Anhedonia Rating Scale (DARS)

+3 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Positive Affect TreatmentExperimental Treatment1 Intervention

8 sessions of psychotherapy designed to augment reward anticipation, reward attainment, and reward learning.

Group II: Positive Affect Treatment and Negative Affect TreatmentActive Control1 Intervention

8 sessions of psychotherapy. 3-5 sessions of psychotherapy designed to augment reward anticipation, reward attainment, and reward learning. Remaining sessions of psychotherapy designed to decrease threat avoidance, threat appraisal and arousal.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Positive Affect Treatment

2019

N/A

~110

0 / 2Eligibility criteria met