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Diagnostic Test

Patients with Elevated Gradients Post Transcatheter Aortic Valve Replacement for Aortic Valve Stenosis (DISCORDANCE Trial)

N/A
Recruiting
Led By David Wood, MD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights
No Placebo-Only Group

Summary

The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.

Eligible Conditions
  • Aortic Valve Stenosis
  • Aortic Stenosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Patient-Prosthesis Mismatch (PPM) reclassification
Transaortic mean gradient reclassification
Transaortic valve gradients
+1 more
Secondary study objectives
Risks of procedural complications
Total procedure time

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients with Elevated Gradients Post Transcatheter Aortic Valve ReplacementExperimental Treatment1 Intervention
Patients who have an echocardiographic transaortic mean gradient ≥ 20mmHg OR VARC-3 criteria for ≥ moderate hemodynamic valve deterioration post TAVR on any TTE \> 1 month post-TAVR

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,466 Previous Clinical Trials
2,485,406 Total Patients Enrolled
4 Trials studying Aortic Valve Stenosis
14,726 Patients Enrolled for Aortic Valve Stenosis
Edwards LifesciencesIndustry Sponsor
182 Previous Clinical Trials
63,058 Total Patients Enrolled
60 Trials studying Aortic Valve Stenosis
32,541 Patients Enrolled for Aortic Valve Stenosis
David Wood, MD2.718 ReviewsPrincipal Investigator - University of British Columbia
University of British Columbia
2 Previous Clinical Trials
311 Total Patients Enrolled
5Patient Review
He was very nice and understanding. He listened to everything I had to say and did a great job of explaining things. The staff was just as awesome.
~12 spots leftby Nov 2025
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