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Treatment Resistant Depression and Obstructive Sleep Apnea, Effect of Continuous Positive Airway Pressure (CPAP)

N/A
Waitlist Available
Led By Ruzica Jokic, MD
Research Sponsored by Queen's University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 6 weeks
Awards & highlights
No Placebo-Only Group

Summary

The purpose of the study is to determine the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD (treatment resistant depression) and associated OSA (obstructive sleep apnea).

Eligible Conditions
  • Obstructive Sleep Apnea
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 6 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
HAM-D21

Side effects data

From 2008 Phase 2 trial • 68 Patients • NCT00047463
9%
skin irritation
5%
nasal congestion
5%
GI discomfort
5%
tachycardia or chest tightness
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo Continuous Positive Airway Pressure
Continuous Positive Airway Pressure

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: CPAP treatmentExperimental Treatment1 Intervention
Continuous Positive Airway Pressure (CPAP)for 4 weeks
Group II: No CPAPActive Control1 Intervention
routine psychiatric care for 4 weeks followed by CPAP titration and initiation after followup measures.
Group III: Control groupActive Control1 Intervention
No obstructive sleep apnea detected.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
continuous positive airway pressure (CPAP)
2008
Completed Phase 4
~240

Find a Location

Who is running the clinical trial?

Queen's UniversityLead Sponsor
375 Previous Clinical Trials
121,633 Total Patients Enrolled
Ruzica Jokic, MDPrincipal InvestigatorQueen's University
~6 spots leftby Jan 2026
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