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Early Rheumatoid Arthritis (RA) for Rheumatoid Arthritis (MusculRA Trial)

N/A
Waitlist Available
Led By Kim M Huffman, MD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights

MusculRA Trial Summary

This trial will study whether early rheumatoid arthritis (RA) patients have different skeletal muscle biomechanical properties than healthy controls, and whether those properties are related to disability and mortality in RA patients.

Eligible Conditions
  • Rheumatoid Arthritis
  • Healthy Controls

MusculRA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Muscle stiffness and elasticity
Secondary outcome measures
Janus kinase/signal transducers and activators of transcription 3 pathway (JAK/STAT3) signaling in skeletal muscle
Myobundle function

MusculRA Trial Design

2Treatment groups
Experimental Treatment
Group I: Early Rheumatoid Arthritis (RA)Experimental Treatment9 Interventions
Early RA defined as duration of disease/symptoms of less than 6 months (where "duration" denotes the length of time the patient has had symptoms/disease, not the length of time since RA diagnosis) AND prior to starting biologic Disease-modifying anti-rheumatic drugs (bDMARD) therapy
Group II: Age-, Sex-, BMI-matched Healthy ControlsExperimental Treatment9 Interventions
Healthy Controls.

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Who is running the clinical trial?

Duke UniversityLead Sponsor
2,381 Previous Clinical Trials
3,427,692 Total Patients Enrolled
11 Trials studying Rheumatoid Arthritis
2,133 Patients Enrolled for Rheumatoid Arthritis
Gilead SciencesIndustry Sponsor
1,085 Previous Clinical Trials
848,124 Total Patients Enrolled
15 Trials studying Rheumatoid Arthritis
7,692 Patients Enrolled for Rheumatoid Arthritis
Kim M Huffman, MDPrincipal InvestigatorDuke University
~4 spots leftby Jun 2025
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