Trial Summary
What is the purpose of this trial?This "How caffeine Induces Atrial Tachyarrhythmias" trial will be a multi-center, randomized, double-blinded trial of intravenous caffeine versus placebo among patients undergoing pulmonary vein isolation procedures for Atrial Fibrillation(AF).
Eligibility Criteria
This trial is for adults aged 21-90 with new or recent onset Paroxysmal Atrial Fibrillation, who are undergoing AF ablation and can give informed consent. It's not for those with substance abuse history, severe caffeine intolerance, pregnancy, poor heart pump function (ejection fraction <50%), liver issues, or recent use of certain heart rhythm drugs.Treatment Details
The study tests the effects of intravenous caffeine on atrial electrical properties and arrhythmia risk during pulmonary vein isolation procedures in AF patients. Participants will be randomly assigned to receive either caffeine or a placebo without knowing which one they're getting.
2Treatment groups
Active Control
Placebo Group
Group I: Group assigned to receive caffeineActive Control1 Intervention
Group II: Group assigned to receive masked placeboPlacebo Group1 Intervention
Find a clinic near you
Research locations nearbySelect from list below to view details:
Texas Cardiac Arrythmia InstituteAustin, TX
Loma Linda UniversityLoma Linda, CA
Kansas City Heart Rhythm InstituteOverland Park, KS
Overland Park Regional Medical CenterOverland Park, KS
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Who is running the clinical trial?
Kansas City Heart Rhythm Research FoundationLead Sponsor
Kansas City Heart Rhythm Institute, Overland Park, KSCollaborator
Texas Cardiac Arrhythmia Institute, Austin, TX, USACollaborator
Loma Linda University, Loma Linda, California, USACollaborator