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EASE for Autism Spectrum Disorder (EASE Trial)

N/A
Waitlist Available
Led By Susan White
Research Sponsored by University of Pittsburgh
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up the cgi-i will be completed at 16 weeks (post-treatment)
Awards & highlights

EASE Trial Summary

This trial will test a new intervention to improve emotion regulation in adolescents with ASD. If successful, this could lead to reduced maladaptive behavior and improved quality of life for those with ASD and their families.

Eligible Conditions
  • Autism Spectrum Disorder
  • Autism

EASE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~the edi-sf will be completed at 16 weeks (post-treatment).
This trial's timeline: 3 weeks for screening, Varies for treatment, and the edi-sf will be completed at 16 weeks (post-treatment). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The Clinical Global Impression Scale- Improvement (CGI-I)
Secondary outcome measures
Brief Psychiatric Rating Scale (BPRS)
Emotion Dysregulation Inventory Reactivity Scale Short Form (EDI-SF)

EASE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Emotion Awareness/Skills EnhancementExperimental Treatment1 Intervention
EASE Therapy includes 16 weekly sessions focused on mindfulness exercise, review of prior content, practicing prior skills, outline of current session, discussion of the new skill, handouts, practice and plan for out of session practice held in Webster Hall in Pittsburgh, at the Center for the Prevention of Youth Behavior Problems in Tuscaloosa or via telehealth conferencing software. The investigators will apply a multimodal teaching approach, where individual therapy is buttressed by parent involvement and practice sessions in the youth's community. A secure website developed for this project (emotion-Coach or "e-Coach") will augment the intervention by providing online supports to increase treatment intensity or dosage. There will be specific information on how to reinforce the skills at home and in the community.
Group II: Supportive TherapyActive Control1 Intervention
Supportive Therapy will involve attending 16 weekly therapy sessions held in Webster Hall in Pittsburgh, at the Center for the Prevention of Youth Behavior Problems in Tuscaloosa or via telehealth conferencing software. The intervention will not involve mindfulness or other emotion regulation strategies used in EASE. The therapy will be tailored to the individual's needs and will include aspects common in supportive therapy such as reflective listening, antecedent management, and problem-solving. This program does not have an online component.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
EASE
2015
N/A
~160

Find a Location

Who is running the clinical trial?

University of PittsburghLead Sponsor
1,731 Previous Clinical Trials
16,307,324 Total Patients Enrolled
15 Trials studying Autism Spectrum Disorder
10,341 Patients Enrolled for Autism Spectrum Disorder
University of Alabama at BirminghamOTHER
1,594 Previous Clinical Trials
2,282,356 Total Patients Enrolled
7 Trials studying Autism Spectrum Disorder
964 Patients Enrolled for Autism Spectrum Disorder
Susan WhitePrincipal InvestigatorUniversity of Alabama at Birmingham
~15 spots leftby Jun 2025
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