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Radiation Therapy

Feasibility Study of FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01 Trial)

N/A
Waitlist Available
Led By John Breneman, MD
Research Sponsored by Varian Medical
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up assessed from start of treatment until subject death or lost to follow-up, up to 17.8 months
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing FLASH radiotherapy, a fast and high-dose radiation treatment, on patients with painful bone cancer in their limbs. The goal is to see if it can relieve pain effectively with fewer side effects. FLASH radiotherapy delivers ultra-high dose rate radiation to reduce damage to healthy tissues while maintaining tumor control.

Eligible Conditions
  • Bone Metastasis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~assessed from start of treatment until subject death or lost to follow-up, up to 17.8 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and assessed from start of treatment until subject death or lost to follow-up, up to 17.8 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Assessment of Radiation-related Toxicities That Are Possibly, Probably, or Definitely Related to FLASH Radiotherapy.
Workflow Feasibility
Secondary study objectives
Number of Participants Who Experienced a Pain Flare.
Number of Participants With Increased Use of Pain Medication in First 10 Days Post FLASH Treatment
Pain Relief

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: FLASH radiotherapy for painful bone metastasis(-es)Experimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
FLASH Radiotherapy
2020
N/A
~10

Find a Location

Who is running the clinical trial?

Varian MedicalLead Sponsor
6 Previous Clinical Trials
320 Total Patients Enrolled
Varian, a Siemens Healthineers CompanyLead Sponsor
34 Previous Clinical Trials
7,217 Total Patients Enrolled
John Breneman, MDPrincipal InvestigatorProfessor of Radiation Oncology and Neurosurgery, UCMC
1 Previous Clinical Trials
10 Total Patients Enrolled
~2 spots leftby Dec 2025
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