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Non-invasive Brain Stimulation
Dorsomedial rTMS For Depression In Borderline Personality Disorder (rTMS Trial)
N/A
Waitlist Available
Led By Dr. Jonathan Downar, MD PhD
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to first followup (1 week post treatment), 3 months post-treatment
Awards & highlights
No Placebo-Only Group
Summary
This trial tests if a treatment using magnetic fields to stimulate brain cells can help people with borderline personality disorder and depression that hasn't improved with medication. The magnetic pulses aim to improve mood by targeting specific brain areas. This non-invasive procedure has shown significant improvements in clinical symptoms of major depressive disorder.
Eligible Conditions
- Borderline Personality Disorder
- Depression
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline to first followup (1 week post treatment), 3 months post-treatment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to first followup (1 week post treatment), 3 months post-treatment
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
HRSD-17 change
Secondary study objectives
ZAN-BPD change
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Group I: Sham -> ActiveExperimental Treatment1 Intervention
15 days of sham, followed by 15 days of active rTMS, targeting dorsomedial prefrontal cortex bilaterally, two sessions per day (1 hour apart), 20 Hz stimulation, at 120% resting motor threshold
Group II: Active -> ShamExperimental Treatment1 Intervention
15 days of active, followed by 15 days of sham rTMS, targeting dorsomedial prefrontal cortex bilaterally, two sessions per day (1 hour apart), 20 Hz stimulation, at 120% resting motor threshold
Find a Location
Who is running the clinical trial?
University Health Network, TorontoLead Sponsor
1,527 Previous Clinical Trials
503,526 Total Patients Enrolled
Dr. Jonathan Downar, MD PhDPrincipal InvestigatorUniversity Health Network, Toronto