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Non-invasive Brain Stimulation

Active -> Sham for Borderline Personality Disorder (rTMS Trial)

N/A
Waitlist Available
Led By Dr. Jonathan Downar, MD PhD
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to first followup (1 week post treatment), 3 months post-treatment
Awards & highlights
No Placebo-Only Group

Summary

This trial tests if a treatment using magnetic fields to stimulate brain cells can help people with borderline personality disorder and depression that hasn't improved with medication. The magnetic pulses aim to improve mood by targeting specific brain areas. This non-invasive procedure has shown significant improvements in clinical symptoms of major depressive disorder.

Eligible Conditions
  • Borderline Personality Disorder
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to first followup (1 week post treatment), 3 months post-treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to first followup (1 week post treatment), 3 months post-treatment for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
HRSD-17 change
Secondary study objectives
ZAN-BPD change

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Sham -> ActiveExperimental Treatment1 Intervention
15 days of sham, followed by 15 days of active rTMS, targeting dorsomedial prefrontal cortex bilaterally, two sessions per day (1 hour apart), 20 Hz stimulation, at 120% resting motor threshold
Group II: Active -> ShamExperimental Treatment1 Intervention
15 days of active, followed by 15 days of sham rTMS, targeting dorsomedial prefrontal cortex bilaterally, two sessions per day (1 hour apart), 20 Hz stimulation, at 120% resting motor threshold

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Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,523 Previous Clinical Trials
503,318 Total Patients Enrolled
Dr. Jonathan Downar, MD PhDPrincipal InvestigatorUniversity Health Network, Toronto
~2 spots leftby Nov 2025
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