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Avocado for Brain Aging (AvoCog Trial)
N/A
Recruiting
Research Sponsored by University of Kansas Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Males and females aged 65-85 years
Be older than 65 years old
Must not have
Central neurological disease such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, brain tumor, etc.
Serious medical risk: cancer requiring chemotherapy or radiation within the past 5 years, recent cardiac event (i.e. heart attack, etc.)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 12 weeks
Awards & highlights
No Placebo-Only Group
Summary
This trial will test if adding avocados to the diet of older adults (65-85) affects cognition; tests include MRI, cognitive tests, blood tests, and questionnaires.
Who is the study for?
This trial is for older adults aged 65-85, in good health with no serious diseases, a BMI of 18.5 - 35, and normal cognitive function (Mini Mental State Exam ≥26). They should eat few avocados and carotenoid-rich foods. Those with latex allergy, taking certain supplements, or having central neurological diseases or recent severe medical conditions cannot join.
What is being tested?
The AvoCog study tests if eating one avocado daily improves brain function in older adults without dementia. It compares an intervention group consuming avocados to a control group maintaining their usual diet over 12 weeks while monitoring changes through MRI scans, cognitive tests, blood flow measurements, and questionnaires.
What are the potential side effects?
Potential side effects are not specified for this trial but may include digestive discomfort due to increased fiber intake from the avocados. Participants will be monitored for any adverse reactions throughout the study.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 65 and 85 years old.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I do not have central nervous system diseases like Alzheimer's, Parkinson's, MS, stroke, or brain tumor.
Select...
I haven't had cancer treatment or a serious heart event in the last 5 years.
Select...
I am not taking any psychoactive or investigational drugs.
Select...
I have diabetes or high blood pressure that is not well-controlled.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline and 12 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 12 weeks
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in brain activity
Secondary study objectives
Changes in cerebral blood flow
Changes in memory and executive function
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Avocado GroupExperimental Treatment1 Intervention
Participants will consume 1 avocado per day and receive education to maintain usual caloric intake for 12 weeks and participate in 4 study visits.
Group II: No Diet Modification GroupActive Control1 Intervention
Participants will continue their normal dietary pattern for 12 weeks and participate in 4 study visits.
Find a Location
Who is running the clinical trial?
Avocado Nutrition CenterUNKNOWN
2 Previous Clinical Trials
464 Total Patients Enrolled
University of Kansas Medical CenterLead Sponsor
517 Previous Clinical Trials
177,371 Total Patients Enrolled
2 Trials studying Brain Aging
133 Patients Enrolled for Brain Aging