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Behavioural Intervention

Olfactory Training for Loss of Smell

N/A
Waitlist Available
Led By Jennifer A Villwock, MD
Research Sponsored by University of Kansas Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to month 6
Awards & highlights
No Placebo-Only Group

Summary

This trial found that olfactory training may help some people recover their sense of smell.

Who is the study for?
This trial is for individuals who have experienced a traumatic brain injury and can perform smell tests. It's not for those under 18 or over 80, pregnant women, people with poor compliance, those unable to do follow-ups, in other studies, or with conditions like dementia or certain sinonasal impacting diseases.
What is being tested?
The study is testing olfactory training - exposing participants to different smells regularly to try and improve their sense of smell after a brain injury. There's no drug involved; it's about retraining the nose.
What are the potential side effects?
Since this trial involves smelling various odors as part of the training process rather than medication, there are no typical drug side effects. However, some may experience discomfort if they're sensitive to particular scents used.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to month 6
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to month 6 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Olfactory Identification
Olfactory Threshold
Secondary study objectives
Neurocognition
Tolerance with Olfactory Training Protocol

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Group A: 4 scentsExperimental Treatment1 Intervention
Participants will be asked to inhale 4 different scents 2 times a day.
Group II: Group B: 14 scentsActive Control1 Intervention
Participants will be asked to inhale 14 different scents 2 times a day.

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Who is running the clinical trial?

University of Kansas Medical CenterLead Sponsor
510 Previous Clinical Trials
176,649 Total Patients Enrolled
Jennifer A Villwock, MDPrincipal InvestigatorUniversity of Kansas Medical Center
~46 spots leftby Dec 2025
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