Radiosurgery for Brain Cancer

Recruiting in Palo Alto (17 mi)

Overseen byJohn A Fiveash, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Alabama at Birmingham

No Placebo Group

Trial Summary

What is the purpose of this trial?Radiosurgery is the use of a focal high dose of radiation therapy to ablate or kill a tumor. This trial will enroll patients with brain metastases 4 cm or less in greatest diameter and will compare 0mm margin to a 2mm margin for treatment.

Eligibility Criteria

This trial is for individuals with brain tumors that have spread (metastases) and are no larger than 4 cm. Specific eligibility details aren't provided, but typically participants must meet certain health standards and not have conditions that could interfere with the study.

Inclusion Criteria

Stated willingness to comply with all study procedures and availability for the duration of the study

My brain cancer has not needed more treatment.

I am 19 years old or older.

+2 more

Exclusion Criteria

My treatment plan may target more than 20 cancer areas after review.

I've had focused radiation before and may need it again.

Inability to have MRI imaging

+6 more

Participant Groups

The trial is testing the effectiveness of radiosurgery, a high-dose radiation treatment aimed at destroying tumors in the brain. It compares two approaches: one uses no extra space around the tumor (0mm margin), while the other includes a small buffer zone (2mm margin).

2Treatment groups

Active Control

Group I: 0mm marginActive Control1 Intervention

For each patient two radiation treatment plans will be created. One will have 0 mm margin for the planning target volume. Tumors will be prescribed based upon the maximum diameter of the largest tumor and location at the discretion of the treating radiation oncologist with the following guidance: \< 2.0 cm diameter 16-20 Gy 2.0-4.0 cm diameter 3 fractions of 9 Gy for total 27 Gy.

Group II: 2mm marginActive Control1 Intervention

For each patient two radiation treatment plans will be created. One will be 2 mm margin for the planning target volume. Tumors will be prescribed based upon the maximum diameter of the largest tumor and location at the discretion of the treating radiation oncologist with the following guidance: \< 2.0 cm diameter 16-20 Gy 2.0-4.0 cm diameter 3 fractions of 9 Gy for total 27 Gy.