Stereotactic Radiosurgery for Brain Metastases

Recruiting in Palo Alto (17 mi)

Overseen bySteve Burton, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Steven Burton

No Placebo Group

Trial Summary

What is the purpose of this trial?This is a research trial that seeks to break up the total radiation dose into multiple smaller radiation treatments, termed fractionated stereotactic radiosurgery (FSRS) which may make the treatment feasible. Fractionated sterotatcic radiation, the risks of FSRS, and possible costs will be described later in this document. This clinical trial is for people who have had no prior whole brain radiation.

Eligibility Criteria

This trial is for adults with brain metastases who have not had whole brain radiation. They should be expected to live at least 12 weeks, be fairly active (Karnofsky score ≥70), and have up to 3 measurable brain lesions, one between 3-5cm. Prior chemotherapy is okay, but no prior radiotherapy or surgery on the target lesion(s). Pregnant or breastfeeding individuals are excluded.

Inclusion Criteria

Must be aware of the neoplastic nature of his/her disease and willingly provide written, informed consent after being informed of the procedure to be followed, the experimental nature of the therapy, alternatives, potential benefits, side-effects, risks and discomforts

The target lesion(s) can be accurately measured in at least one dimension according to RECIST

I am 18 years old or older.

+9 more

Exclusion Criteria

I have four or more new lesions.

I need surgery for my main cancer lesion because it's causing symptoms.

I have had surgery to remove a specific tumor.

+4 more

Participant Groups

The study tests fractionated stereotactic radiosurgery (FSRS) which divides the total radiation dose into smaller treatments for large brain metastases. The goal is to see if FSRS can treat larger tumors that typically wouldn't be candidates for single-dose radiosurgery.

1Treatment groups

Experimental Treatment

Group I: Fractionated Stereotactic RadiosurgeryExperimental Treatment1 Intervention

24 to 36 Gy in 3 fractions (8-12 Gy/fx).