Partial Breast Irradiation for Breast Cancer

(PBSI Trial)

Recruiting in Palo Alto (17 mi)

Overseen by Juanita Crook, MD

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: British Columbia Cancer Agency

No Placebo Group

Trial Summary

What is the purpose of this trial?

Permanent Breast Seed Implant (PBSI) has been demonstrated to be a well accepted and well tolerated form of partial breast radiotherapy. This protocol aims to build on the initial experience and to further refine the technique and collect toxicity and cost data, especially in comparison to alternate forms of breast radiotherapy.

Eligibility Criteria

This trial is for postmenopausal women over 55 with early-stage breast cancer (Stage 0 or I, tumor <2cm) that's been surgically removed with clear margins. Participants must have a life expectancy of at least ten years and cannot have had certain other cancers unless disease-free for five years. Those with genetic mutations in BRCA, high-grade tumors, unclear surgical sites, or previous chest radiotherapy are excluded.

Inclusion Criteria

My breast cancer is either DCIS or invasive ductal adenocarcinoma.

My lumpectomy cavity is less than 3 cm across and can be seen clearly on scans.

My cancer is low or intermediate grade.

Exclusion Criteria

My condition is extensive DCIS (a type of breast cancer).

My cancer has spread to my lymph nodes or blood vessels.

I have cancer in both breasts at the same time.

Participant Groups

The study tests a type of partial breast radiation therapy using Palladium-103 seed implants after lumpectomy in patients with specific types of breast cancer. It aims to refine the technique and gather data on its side effects and costs compared to other treatments.

Group I: Breast seed implant Experimental Treatment 3 Interventions

Stranded palladium seed interstitial radioactive seed implant to seroma with margin with 3 dimensional ultrasound and CT guidance

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

BCCA Center for the Southern Interior Kelowna, Canada

Who Is Running the Clinical Trial?

British Columbia Cancer Agency Lead Sponsor

References