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Photon Therapy

Proton vs. Photon Therapy for Breast Cancer

N/A
Waitlist Available
Led By Alexander Lin, MD
Research Sponsored by Abramson Cancer Center at Penn Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Must be proceeding with breast/chest wall and nodal radiation therapy including internal mammary node treatment
Females or males diagnosed with pathologically (histologically) proven invasive mammary carcinoma (ductal, lobular or other) of the breast who have undergone either mastectomy or lumpectomy with any type of axillary surgery or axillary sampling
Must not have
Any radiation therapy for the currently diagnosed breast cancer prior to randomization
Dermatomyositis with a CPK level above normal or with an active skin rash or scleroderma
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 15 years
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing whether proton therapy or photon therapy is better for treating breast cancer. It will follow patients for side effects, quality of life, and cancer control.

Who is the study for?
This trial is for adults (21+) with non-metastatic breast cancer, regardless of surgery type or breast size. Participants must be planning radiation therapy and have insurance coverage for the treatments tested. People with HIV can join if treated and meet certain health criteria. Excluded are those with prior chest radiation, current metastases, or specific autoimmune conditions.
What is being tested?
The study compares proton therapy to photon therapy in treating locally advanced breast cancer, focusing on long-term heart health, quality of life, and effectiveness in controlling cancer.
What are the potential side effects?
While not specified here, common side effects from radiation therapies like proton and photon may include skin changes at the treatment site, fatigue, mild swelling in the treated area, and a temporary change in breast color.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am scheduled for radiation therapy on my breast/chest and lymph nodes, including the internal mammary nodes.
Select...
I have been diagnosed with breast cancer and have had surgery to remove it.
Select...
I have non-metastatic breast cancer at stage I, II, III, or loco-regionally recurrent.
Select...
I am 21 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have not received radiation for my current breast cancer before joining this study.
Select...
I have dermatomyositis with high CPK levels or an active rash, or I have scleroderma.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~15 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 15 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Effectiveness of proton therapy vs. photon therapy
Secondary study objectives
Disease Control
Long Term Survival
Fatigue
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: PhotonActive Control1 Intervention
Photon therapy: once a day, 5 days a week, for 5 to 7 weeks
Group II: ProtonActive Control1 Intervention
Proton therapy: once a day, 5 days a week, for 5 to 7 weeks

Find a Location

Who is running the clinical trial?

Abramson Cancer Center at Penn MedicineLead Sponsor
418 Previous Clinical Trials
462,884 Total Patients Enrolled
46 Trials studying Breast Cancer
359,649 Patients Enrolled for Breast Cancer
Patient-Centered Outcomes Research InstituteOTHER
580 Previous Clinical Trials
27,104,021 Total Patients Enrolled
7 Trials studying Breast Cancer
1,497,555 Patients Enrolled for Breast Cancer
Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
107,117 Total Patients Enrolled
40 Trials studying Breast Cancer
34,075 Patients Enrolled for Breast Cancer
Alexander Lin, MDPrincipal InvestigatorAbramson Cancer Center at Penn Medicine
4 Previous Clinical Trials
230 Total Patients Enrolled
Bonnie Ky, MDPrincipal InvestigatorAbramson Cancer Center at Penn Medicine
4 Previous Clinical Trials
1,024 Total Patients Enrolled
3 Trials studying Breast Cancer
926 Patients Enrolled for Breast Cancer
Oren Cahlon, MDStudy ChairNYU Langone
Justin Bekelman, MDPrincipal InvestigatorAbramson Cancer Center at Penn Medicine
2 Previous Clinical Trials
1,193 Total Patients Enrolled
Shannon MacDonald, MDStudy ChairMassachusetts General Hospital
2 Previous Clinical Trials
65 Total Patients Enrolled

Media Library

Photon (Photon Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT02603341 — N/A
Breast Cancer Research Study Groups: Photon, Proton
Breast Cancer Clinical Trial 2023: Photon Highlights & Side Effects. Trial Name: NCT02603341 — N/A
Photon (Photon Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02603341 — N/A
~355 spots leftby Aug 2028
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