Personalized Molecular Profiling for Breast Cancer
(IMAGE-II Trial)

Recruiting in Palo Alto (17 mi)

+2 other locations

Vered Stearns | Breast Cancer Research ...

Overseen byVered Stearns, M.D.

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

No Placebo Group

Trial Summary

What is the purpose of this trial?

The goal of this research study is to determine if we can obtain personalized genetic information from a subject's blood sample that is similar to that obtained from a tumor tissue sample, and if we can use that information to make treatment suggestions.

Research Team

Vered Stearns, M.D.

Principal Investigator

Johns Hopkins University

Jenna Canzoniero, MD

Principal Investigator

SKCCC Johns Hopkins Medical Institution

Eligibility Criteria

This trial is for adults over 18 with metastatic breast cancer who've had a tumor biopsy in the last 3 years and have available tissue. It's open to all clinical phenotypes of breast cancer, including Triple negative, Hormone receptor positive, and HER2-positive patients who've previously undergone chemotherapy. Pregnant or nursing women are excluded.

Inclusion Criteria

Able to voluntarily provide informed consent

My breast cancer is either triple negative, hormone receptor positive, or HER2 positive.

I have metastatic breast cancer and have had chemotherapy before.

See 2 more

Exclusion Criteria

I am not pregnant or nursing.

Treatment Details

Interventions

Personalized Molecular Profiling (Genetic Testing)

Trial OverviewThe study aims to see if genetic information from blood samples can match that from tumor tissues and whether this data can guide treatment recommendations for individuals with metastatic breast cancer.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Genetic profilingExperimental Treatment1 Intervention

All participants will undergo genetic profiling. Archival tissue will be requested to undergo routine review for possible treatment recommendations. Blood samples will be obtained to study research correlates (plasma tumor DNA, ptDNA) and tissue comparison.