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Boost to the tumour bed for Breast Cancer (TARGIT-B Trial)

N/A
Waitlist Available
Led By Jayant S Vaidya, MBBS FRCS
Research Sponsored by University College, London
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up five year median follow-up.
Awards & highlights

Summary

This trial is testing whether a single dose of targeted intraoperative radiotherapy (TARGIT-B) is superior to the conventional course of external beam radiotherapy boost (EBRT-Boost) for women with a high risk of local recurrence after breast conserving surgery.

Eligible Conditions
  • Breast Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~five year median follow-up
This trial's timeline: 3 weeks for screening, Varies for treatment, and five year median follow-up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Local tumour control (defined as no recurrent tumour in the ipsilateral breast).
Secondary outcome measures
Adverse events related to the primary treatment of the breast cancer.
Overall survival
Quality of life assessed by patient completed validated questionnaires.
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: TARGITExperimental Treatment1 Intervention
The experimental policy is to give targeted intra-operative radiotherapy (TARGIT-Boost) in a single dose to substitute for the usual boost dose, in addition to whole breast external beam radiotherapy delivered according to local treatment guidelines.
Group II: External beam radiotherapy boostActive Control1 Intervention
The conventional policy is to receive radiation boost to the tumour bed delivered by external beam radiotherapy (EBRT) in addition to whole breast external beam radiotherapy delivered according to local treatment guidelines.

Find a Location

Who is running the clinical trial?

University College, LondonLead Sponsor
857 Previous Clinical Trials
38,939,295 Total Patients Enrolled
5 Trials studying Breast Cancer
15,770 Patients Enrolled for Breast Cancer
National Institute for Health Research, United KingdomOTHER_GOV
416 Previous Clinical Trials
16,507,730 Total Patients Enrolled
4 Trials studying Breast Cancer
36,029 Patients Enrolled for Breast Cancer
Jayant S Vaidya, MBBS FRCSPrincipal InvestigatorUniversity College, London
~147 spots leftby Sep 2025
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