Study of Cardiopulmonary Exercise Testing in Women Who Have HER2-Positive Breast Cancer With Mild Cardiotoxicity

Recruiting in Palo Alto (17 mi)

Overseen byAnthony Yu, MD

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

The purpose of this study is to find out how much oxygen is used during a cardiopulmonary exercise test (CPET) in women who have mild cardiotoxicity after standard treatment for HER2-positive breast cancer, and to see whether the results of this test can be used to predict how well participants' heart and lungs will work if they continue to receive this kind of treatment.

Research Team

Anthony Yu, MD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Eligibility Criteria

Inclusion Criteria

Age ≥ 18 years

Female

Diagnosed with a HER2-positive solid tumor (stage I-IV)

See 3 more

Treatment Details

Interventions

Cardiopulmonary Exercise Test (Procedure)
Echocardiogram (Procedure)
Echocardiography (Procedure)

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Participants with HER2-positive breast cancerExperimental Treatment3 Interventions

Participants with HER2-positive breast cancer who have developed mild cardiotoxicity during HER2-targeted therapy, defined by a decline in LVEF \> 10% to \< 53% without symptoms of clinical heart failure (NYHA class III or IV), will be eligible for participation in this study.