Online Dietary & Resistance Training for Older Cancer Survivors

(E-PROOF Trial)

Overseen by Jessica L. Krok-Schoen, PhD

Age: 65+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Ohio State University Comprehensive Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

This phase I trial tests the feasibility, acceptability, and preliminary effectiveness of online dietary and resistance training to improve physical function in older (greater than or equal to 65-years old) cancer survivors. Declines in adequate protein and calorie intake results in faster loss of muscle mass and physical functioning in older adults. A novel approach to improving physical function in older cancer survivors (OCS) is to utilize online, tailored education and counseling from registered dietitians and exercise scientists, to improve dietary intake (protein intake, diet quality) and participation in resistance exercise. The purpose of this study is to help researchers learn whether an online dietary and resistance training intervention improves diet, exercise, physical function, and health outcomes in OCS.

Research Team

Jessica L. Krok-Schoen, PhD

Principal Investigator

Ohio State University Comprehensive Cancer Center

Eligibility Criteria

This trial is for older cancer survivors (65+ years) who've had stage I-III breast, colorectal, or prostate cancer and finished treatment. They must have some physical function limitations but no progressive disease or other cancers. It's not for those on current cancer treatments, with liver/renal issues affecting protein intake, under a dietitian's care, in other diet/exercise studies, or unable to exercise without help.

Inclusion Criteria

I am 65 years old or older.

You have reported having at least one physical limitation on the RAND-36 Physical Function Subscale, such as being limited a little or a lot in your abilities.

My cancer is in the early to mid stages and is either breast, colorectal, or prostate cancer.

Exclusion Criteria

I am currently undergoing cancer treatment.

I must limit my protein intake due to liver or kidney disease.

Using protein supplements.

Treatment Details

Interventions

• Online Dietary and Resistance Training (Behavioural Intervention)

Trial Overview The E-PROOF Trial tests an online program combining dietary guidance from dietitians and resistance training led by exercise scientists to see if it improves the physical function of older cancer survivors. The focus is on enhancing protein intake and quality of diet while engaging participants in home-based exercises.

Participant Groups

Group I: Arm 1 (nutritional counseling, resistance training) Experimental Treatment 6 Interventions

Patients participate in online nutritional counseling over 30 minutes in weeks 1, 3, 5, 7, 9, and 11, and participate in online resistance training sessions weekly over 30 minutes in weeks 1-6 and biweekly at weeks 8, 10, and 12. Patients also receive educational materials at baseline.

Group II: Arm 2 (educational materials) Active Control 4 Interventions

Patients receive educational materials at baseline.

Who Is Running the Clinical Trial?

Ohio State University Comprehensive Cancer Center

Lead Sponsor

Trials

350

Recruited

295,000+

National Institute on Aging (NIA)

Collaborator

Trials

1,841

Recruited

28,150,000+