Virtual Exercise for Chemobrain

Recruiting in Palo Alto (17 mi)

Overseen byJinbing Bai, PhD, RN

Age: < 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Emory University

No Placebo Group

Trial Summary

What is the purpose of this trial?This clinical trial evaluates the impact of a research intervention of virtually supervised exercise program (RISE) on cancer-related cognitive impairment (CRCI), physical activity in adolescent and young adult (AYA) brain tumor survivors. This clinical trial also evaluates the impact of RISE on the collection of microorganisms that exist in the intestines (gut microbiome). Up to 45% of AYA brain tumor survivors experience CRCI, including issues with attention and memory. CRCI can have a negative impact on education, independent living and can worsen long-term quality of life. Moderate-intensity levels of exercise, particularly aerobic and resistance training, have been shown to improve cognitive function. Additionally, exercise can change the composition and function of the gut microbiome, which may lead to improved cognitive function. Unfortunately, only about 50% of AYAs with cancer receive exercise information or meet the physical activity recommendations. Tailoring a virtually delivered exercise intervention to meet the unique needs of AYAs may improve access to exercise. Participating in the virtual home-based exercise intervention, RISE, may improve physical activity and cognitive impairment in AYA brain tumor survivors and may also help researchers understand the relationship of exercise on the gut microbiome and cognitive function.

Eligibility Criteria

This trial is for adolescent and young adult brain tumor survivors who experience cognitive issues like trouble with attention and memory. Participants should be interested in a virtual exercise program to potentially improve these symptoms.

Inclusion Criteria

I had brain radiation therapy between 6 months and 4 years ago.

I am between 15 and 39 years old.

Able to provide informed consent/assent

+5 more

Exclusion Criteria

I have a genetic condition or a second cancer, or need more brain radiation.

I have a brain injury that is more severe than what my brain tumor and its treatment would cause.

Developmental disorders (e.g., autism) or major psychotic illness (e.g., schizophrenia, depression) to avoid confounding impact related to these disorders

Participant Groups

The RISE program, a home-based virtual exercise intervention, is being tested to see if it can help with cancer-related cognitive impairment and alter the gut microbiome in young brain tumor survivors.

2Treatment groups

Experimental Treatment

Active Control

Group I: Arm I (RISE)Experimental Treatment5 Interventions

Patients receive access to Physitrack and participate in personalized, progressive aerobic training over 30-40 minutes 3-5 days a week and strength training exercises 2 days a week for 12 weeks. Patients also receive active lifestyle behavior coaching over 10 minutes on 2 days a week for weeks 1-4 and then once weekly for weeks 5-12.

Group II: Arm II (attention control)Active Control3 Interventions

Patients receive calls from the trainer once weekly for 12 weeks. Patients also wear a Fitbit for 7 days at baseline to week 12.