What side effects are associated with this type of intervention?

The most common treatments for Cervical Adenocarcinoma, such as chemotherapy and radiation therapy, often lead to side effects including nausea, vomiting, fatigue, pain, and emotional distress. Integrative therapies like yoga, meditation, and controlled breathing can help manage these side effects by improving physical and emotional well-being, reducing stress, and enhancing overall quality of life. These complementary approaches are generally well-tolerated and can be beneficial adjuncts to conventional cancer treatments.

What prior FDA approvals exist?

FDA-approved treatments for cervical adenocarcinoma primarily include surgical interventions, radiation therapy, and chemotherapy. Common chemotherapeutic agents include cisplatin, paclitaxel, and topotecan. While these treatments are effective in targeting cancer cells, they do not inherently incorporate holistic approaches like yoga therapy. However, integrative therapies such as yoga, which focus on balancing the mind and body through exercise, meditation, and controlled breathing, are often used as complementary treatments to improve the physical and emotional well-being of patients undergoing conventional cancer treatments.

What other types of research exist?

Promising alternatives to Yoga Therapy for Cervical Adenocarcinoma patients include: <ol> <li>Mindfulness-Based Stress Reduction (MBSR): This therapy involves mindfulness meditation and has shown broad symptom improvement in cancer survivors.</li> <li></li> </ol> Tai Chi: This practice combines gentle physical exercise and stretching with mindfulness and controlled breathing, beneficial for cancer-related fatigue and overall well-being. 3. Acupuncture: Effective for managing symptoms such as pain and fatigue, acupuncture can complement conventional treatments. 4. Music Therapy: This therapy can improve psychological and physical outcomes, including pain relief and emotional well-being. 5. Massage Therapy: Known to reduce pain and improve mood, massage therapy can be a supportive care option.

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Yoga Therapy for Cervical Cancer

Q: What is the mechanism of action of this treatment?

Common treatments for Cervical Adenocarcinoma include surgery, radiation therapy, and chemotherapy. Surgery involves the physical removal of cancerous tissues, radiation therapy uses high-energy rays to kill cancer cells, and chemotherapy employs drugs to target and destroy cancer cells. These treatments can be physically and emotionally taxing. Integrative therapies like yoga, which focus on balancing the mind and body through exercise, meditation, and controlled breathing, can help manage treatment-related symptoms, reduce stress, and improve overall quality of life. This holistic approach is particularly beneficial for Cervical Adenocarcinoma patients as it supports both physical recovery and emotional resilience during conventional cancer treatments.

N/A

Waitlist Available

Led By Lois M Ramondetta

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Score of =< 2 on Eastern Cooperative Oncology Group (ECOG) performance scale

Federation of Gynecology and Obstetrics (FIGO) stage IB2 through IIIB biopsy-proven CxCa (adenocarcinoma, squamous cell carcinoma, and adenosquamous) with plan to undergo curative outpatient CRT at main campus MD Anderson Cancer Center

Must not have

Patients with extreme mobility issues

Prior hysterectomy

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline up to 3 months post crt

Awards & highlights

No Placebo-Only Group

Summary

This trial studies how yoga therapy can help patients with advanced cervical cancer who are receiving chemotherapy and radiation. Yoga involves exercises, meditation, and breathing techniques to improve physical and emotional well-being. The goal is to see if yoga can reduce stress, anxiety, and pain, and enhance overall quality of life during treatment. Yoga has been shown to provide physical and psychological benefits for cancer patients, including reducing fatigue, stress, and improving quality of life.

Who is the study for?

This trial is for English-speaking patients with stage IB2-IIIB cervical cancer who are fit enough to undergo chemotherapy and radiation (ECOG score ≤2). They must be treated at MD Anderson Cancer Center and not have had a hysterectomy, neuroendocrine histology, severe psychiatric conditions, extreme mobility issues, or a regular yoga practice recently.

What is being tested?

The study examines the effectiveness of yoga therapy as an addition to standard chemotherapy and radiation in improving physical and emotional well-being. It involves exercise, meditation, breathing control during cancer treatment.

What are the potential side effects?

Yoga is generally safe but may include muscle soreness or strain. Emotional side effects could arise from confronting difficult emotions during meditation. The risk of injury exists if poses are performed incorrectly.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I can do most things for myself but might be unable to do heavy physical work.

Select...

My cervical cancer is stage IB2 to IIIB and I plan to have treatment aimed at curing it at MD Anderson.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have severe difficulty moving around.

Select...

I have had a hysterectomy.

Select...

My cancer is of neuroendocrine type.

Select...

I have a health condition that prevents me from receiving full-dose chemotherapy.

Select...

I have been diagnosed with another type of cancer besides the one being treated.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline up to 3 months post crt

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline up to 3 months post crt

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to 3 months post crt for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Adherence to the yoga therapy protocol

Completion in the yoga therapy protocol

Yoga

Secondary study objectives

Brief Fatigue Inventory Scale

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Group I (yoga group)Experimental Treatment5 Interventions

Patients attend at least 2 yoga classes per week over 5-6 weeks lasting approximately 60 minutes each for up to 15 classes during the CRT. Patients also complete surveys pre-treatment, once a week, and post-treatment over and receive a yoga manual and DVD during and after CRT.

Group II: Group II (wait list control)Active Control4 Interventions

Patients refrain from participating in any new stress management activities and receive a DVD. Patients are also offered 4 group yoga classes after 3 months of CRT. Patients also complete surveys as in Group I.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Yoga

2008

Completed Phase 3

~3830

0 / 7Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for Cervical Adenocarcinoma include surgery, radiation therapy, and chemotherapy. Surgery involves the physical removal of cancerous tissues, radiation therapy uses high-energy rays to kill cancer cells, and chemotherapy employs drugs to target and destroy cancer cells. These treatments can be physically and emotionally taxing. Integrative therapies like yoga, which focus on balancing the mind and body through exercise, meditation, and controlled breathing, can help manage treatment-related symptoms, reduce stress, and improve overall quality of life. This holistic approach is particularly beneficial for Cervical Adenocarcinoma patients as it supports both physical recovery and emotional resilience during conventional cancer treatments.

Nonpharmacologic complementary therapies in symptom management for breast cancer survivors.Integrative medicine: complementary therapies and supplements.Proportion of gynecologic cancer patients using complementary and alternative medicine.