Preoperative Breast MRI for Breast Cancer

Recruiting in Palo Alto (17 mi)

+3 other locations

Overseen ByKimberly Van Zee, MD

Age: 18 - 65

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group

Approved in 1 jurisdiction

Trial Summary

What is the purpose of this trial?Breast MRI is a fairly new technology, but it has been well studied. It is now used routinely in many patients with breast cancer. It has been shown to be useful in detecting areas of cancer that cannot be seen using other types of scans or tests. The purpose of this study is to see how often MRI can find other areas of cancer in women with one area of breast cancer, and to determine how having the MRI test affects their treatment. The purpose is also to study any areas of abnormality seen on your MRI with special methods that allow the images of your breast tissue and the microscopic analysis of your breast tissue to be compared very carefully. The study also aims to follow women who enter the study over a 10-year period to determine how often the breast cancer comes back.

Eligibility Criteria

This trial is for women under 60 with a specific breast cancer diagnosis (DCIS or DCIS with microinvasion) who haven't had certain biopsies or surgeries yet. They must be able to have breast surgery at MSKCC and not be pregnant, nursing, or have conditions that make MRI unsafe like pacemakers, metal implants, severe weight over 350 lb., allergies to MRI contrast agents, or metal in the eye.

Inclusion Criteria

I am under 60 years old.

I am female.

My breast surgery will be done at MSKCC.

My breast cancer is in a very early stage, confirmed by a core biopsy.

My cancer was diagnosed at an early stage.

Exclusion Criteria

I am 60 years old or older.

I cannot have breast-saving surgery due to my condition.

I had a surgical biopsy for DCIS or DCIS with slight invasion before joining.

Participant Groups

The study tests how effective Breast MRI is in detecting additional cancer areas in women already diagnosed with one area of breast cancer. It examines if the MRI influences treatment decisions and compares image findings with microscopic tissue analysis. Participants will also be followed for ten years to monitor cancer recurrence.

1Treatment groups

Experimental Treatment

Group I: 1Experimental Treatment1 Intervention

Women with core biopsy proven DCIS with or without microinvasion seen for surgical consultation at Memorial Sloan-Kettering Cancer Center and for whom operative intervention is planned.