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Dietary Supplement

Beta-glucan for Lung Cancer

N/A

Recruiting

Led By Goetz H Kloecker, MD

Research Sponsored by University of Louisville

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Suspected or definitive diagnosis of non-small cell lung cancer (NSCLC)

Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3

Must not have

Currently receiving continuous corticosteroids or other ongoing immunosuppressive therapy

Presence of an uncontrolled intercurrent illness including but not limited to: ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

Timeline

Screening 3 weeks

Treatment Varies

Follow Up post-treatment

Awards & highlights

No Placebo-Only Group

Summary

This trial will study how well beta-glucan works in boosting the immune system of people with non-small cell lung cancer.

Who is the study for?

This trial is for adults who can swallow pills, have a certain level of physical fitness (ECOG 0-3), and enough white blood cells (ANC at least 1500/microl). They must be able to consent, have operable non-small cell lung cancer, and not received treatment in the last 6 months. It's not for those allergic to beta-glucan or on steroids/immunosuppressants, or with uncontrolled illnesses or psychiatric conditions.

What is being tested?

The study is testing how beta-glucan affects the immune system in patients with non-small cell lung cancer. Participants will take beta-glucan orally to see if it helps their body fight cancer.

What are the potential side effects?

Potential side effects are not specified but may include reactions related to immune system changes due to beta-glucan. Patients with previous hypersensitivity reactions to beta-glucan are excluded from the trial.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with non-small cell lung cancer.

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I can care for myself but may not be able to do heavy physical work.

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My lung cancer can be removed with surgery, as confirmed by a thoracic surgeon.

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I am fit for surgery.

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I can swallow pills.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am currently on continuous corticosteroids or other immunosuppressive drugs.

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I do not have any severe illnesses that could interfere with the study.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ pre-treatment and post-treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~pre-treatment and post-treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-treatment and post-treatment for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

blood specimens will be obtained to examine the ability of beta-glucan to prime neutrophils complement receptor 3 (CR3) and test the cytotoxicity of the primed neutrophils.

resected lung tissue will be tested to determine macrophage phenotype