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Cardiac amyloidosis for Paraproteinemia (PICA-CMR Trial)

N/A
Waitlist Available
Led By Robert E O'Donnell, MD MSc
Research Sponsored by University of Cincinnati
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Subjects meeting diagnostic criteria for the target population will be recruited for the study. Age range will be 18 to 85 years of age.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

Cardiac amyloidosis describes a process by which abnormally folded proteins infiltrate the heart tissue. Given the insidious nature of this disease process, diagnosis is often too late for a meaningful intervention. Advances in the treatment of the amyloidoses have improved outcomes for patients with these conditions. The focus of this study is to identify the involvement of the heart, most closely associated with mortality, so that aggressive management can be instituted improving prognosis.

Eligible Conditions
  • Paraproteinemia
  • Amyloid Cardiomyopathy
  • Amyloidosis
  • Cardiomyopathy

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Cardiac amyloidosisExperimental Treatment1 Intervention
Patients being managed for cardiac amyloidosis
Group II: AmyloidosisExperimental Treatment1 Intervention
Patients being managed for amyloidosis without prior history of cardiac involvement

Find a Location

Who is running the clinical trial?

University of CincinnatiLead Sponsor
438 Previous Clinical Trials
638,688 Total Patients Enrolled
The Christ HospitalOTHER
19 Previous Clinical Trials
1,393 Total Patients Enrolled
Jennifer Daniels, MScStudy DirectorUniversity of Cincinnati
~0 spots leftby Dec 2025
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