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Cardiac Rehabilitation for Cardiovascular Disease

N/A
Recruiting
Led By Bruce D Johnson, PhD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients with Cardiovascular Disease: Aged 40-years and older. Eligible for cardiac rehabilitation following a cardiac-related hospital admission, coronary artery disease (including angina, myocardial infarction, percutaneous coronary intervention, or coronary artery bypass graft surgery).
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and follow-up at 3-months

Summary

This trial will help researchers understand how cardiovascular disease affects brain blood flow and cognition, as well as whether exercise can improve brain blood flow and cognition.

Who is the study for?
This trial is for people aged 40 and older who are eligible for cardiac rehab after a heart-related hospital stay. It's open to those with coronary artery disease but not to individuals previously diagnosed with cardiovascular diseases or risk factors like high blood pressure, high cholesterol, diabetes, obesity (BMI >30), or smoking.
What is being tested?
The study tests how different intensities of exercise in cardiac rehabilitation affect brain blood flow and cognitive function. Participants will be observed during regular control sessions, high intensity interval training (HIIT), and moderate intensity continuous training (MICT).
What are the potential side effects?
While the trial itself does not list specific side effects, typical risks associated with exercise may include muscle soreness, fatigue, shortness of breath during activity, and in rare cases, heart-related events.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am over 40 and qualify for heart rehab after a heart-related hospital stay.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and follow-up at 3-months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and follow-up at 3-months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cerebral blood flow regulation (as cerebrovascular reactivity)
Secondary study objectives
Cognitive function
Other study objectives
Cerebral blood flow regulation (as autoregulation)
Cerebral blood flow regulation (as neurovascular coupling)
Cerebral blood flow regulation to exercise
+2 more

Trial Design

5Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Cardiac rehabilitation - observationalExperimental Treatment1 Intervention
This observational group will include patients who are completing an exercise-based cardiac rehabilitation program in line with standard care but are not part of the randomized exercise protocol groups (HIIT or MICT). Participants in this group will be combined with HIIT and MICT (as exercise-based cardiac rehabilitation group) for Aims 1b and 2b.
Group II: Cardiac rehabilitation - High intensity interval training (HIIT)Experimental Treatment1 Intervention
Patients attending cardiac rehabilitation randomized to HIIT.
Group III: Healthy control groupActive Control1 Intervention
Healthy age-matched adults without cardiovascular disease, who will complete baseline assessments only. No intervention period.
Group IV: Cardiac rehabilitation - Moderate intensity continuous training (MICT)Active Control1 Intervention
Patients attending cardiac rehabilitation randomized to MICT.
Group V: Cardiac rehabilitation - controlPlacebo Group1 Intervention
The control group (12 week period) will include participants who have declined cardiac rehabilitation.

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,324 Previous Clinical Trials
3,059,292 Total Patients Enrolled
Bruce D Johnson, PhDPrincipal InvestigatorMayo Clinic
1 Previous Clinical Trials
80 Total Patients Enrolled

Media Library

Cardiac rehabilitation - control Clinical Trial Eligibility Overview. Trial Name: NCT05012878 — N/A
Cardiovascular Disease Research Study Groups: Healthy control group, Cardiac rehabilitation - Moderate intensity continuous training (MICT), Cardiac rehabilitation - High intensity interval training (HIIT), Cardiac rehabilitation - control, Cardiac rehabilitation - observational
Cardiovascular Disease Clinical Trial 2023: Cardiac rehabilitation - control Highlights & Side Effects. Trial Name: NCT05012878 — N/A
Cardiac rehabilitation - control 2023 Treatment Timeline for Medical Study. Trial Name: NCT05012878 — N/A
~4 spots leftby Dec 2024
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