Carpal Tunnel Release for Carpal Tunnel Syndrome
(MISSION Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial gathers real-world data on carpal tunnel release (CTR) surgeries to better understand patient experiences. It compares three surgery methods: ultrasound-guided, open, and endoscopic. The goal is to assess how each method affects recovery and outcomes over time. Individuals with diagnosed carpal tunnel syndrome (characterized by pain and numbness in the hand due to nerve compression) who have not found relief from other treatments might be suitable candidates. Participants must be willing to complete follow-up surveys for two years. As an unphased trial, this study offers participants the chance to contribute valuable insights that could enhance future treatment options.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that ultrasound-guided carpal tunnel release (CTR-US) is safe and effective. Studies find it easy for patients to handle, providing long-lasting symptom relief with a low risk of complications. Patients report high satisfaction with this method.
For open carpal tunnel release (OCTR), evidence suggests it is a reliable and safe option. Many patients experience significant symptom reduction, and the procedure has a strong safety record with fewer complications.
Endoscopic carpal tunnel release (ECTR) is also considered safe. Patients often experience less post-surgery pain and report higher satisfaction. However, there is a slightly higher chance of temporary nerve issues compared to open surgery. Overall, all these methods are regarded as safe, each with its own benefits and risks.12345Why are researchers excited about this trial?
Researchers are excited about these methods for carpal tunnel release because they offer less invasive options compared to traditional surgery. The Ultrasound Guided Carpal Tunnel Release (CTR-US) technique uses imaging to precisely guide the procedure, potentially reducing recovery time and minimizing scarring. The Endoscopic Carpal Tunnel Release (ECTR) allows for a smaller incision, which can lead to quicker healing and less post-operative discomfort. These innovative approaches aim to improve patient outcomes and enhance the overall experience compared to the standard open surgical method.
What evidence suggests that this trial's treatments could be effective for carpal tunnel release?
This trial will compare three techniques for carpal tunnel release: Ultrasound Guided Carpal Tunnel Release (CTR-US), Open Carpal Tunnel Release (OCTR), and Endoscopic Carpal Tunnel Release (ECTR). Research has shown that ultrasound-guided carpal tunnel release (CTR-US) is safe and effective, with benefits lasting up to 6 years. Six months post-procedure, about 94% of patients reported satisfaction. Open carpal tunnel release (OCTR) has shown good long-term results, with a success rate of 75% to 90%. In some cases, endoscopic carpal tunnel release (ECTR) performs even better, with 82% of patients experiencing complete symptom relief and faster recovery. Both OCTR and ECTR are effective, but ECTR often results in better recovery and less scarring pain.16789
Who Is on the Research Team?
Victor M Marwin, MD, MBA
Principal Investigator
Bluegrass Orthopaedics
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo carpal tunnel release using one of three techniques: Ultrasound guided, Endoscopic, or Open
Follow-up
Participants are monitored for safety, effectiveness, and satisfaction after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Endoscopic CTR
- Open CTR
- UltraGuideCTR with Ultrasound Guided Carpal Tunnel Release (CTR-US)
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Carpal Tunnel Release using CTR-US technique
Carpal Tunnel Release Using Open Carpal Tunnel Release (OCTR)
Carpal Tunnel Release Using Endoscopic Carpal Tunnel Release (ECTR)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Sonex Health, Inc.
Lead Sponsor
Citations
Improved Surgical Outcomes With Endoscopic Carpal Tunnel ...
Treatment completely resolved CTS symptoms in 82% of ECTR cases and 39% of OCTR cases. Complication rates (all causes) were similar for both procedures.
Outcomes Following Endoscopic versus Open Carpal ...
However, patients undergoing ECTR have significantly lower rates of infection, wound complications, and readmission within 30 days. Despite the increased cost ...
3.
journals.lww.com
journals.lww.com/prsgo/fulltext/2025/06000/comparing_the_efficacy_of_endoscopic_carpal_tunnel.78.aspxComparing the Efficacy of Endoscopic Carpal Tunnel ...
Both ECTR and OCTR are safe and effective in management of carpal tunnel syndrome. However, ECTR may be slightly superior in terms of scar pain ...
Best-Evidence Systematic Review and Meta-Analysis ...
In a best-evidence synthesis of contemporary studies, ECTR resulted in significant improvements in function and pain, with a low risk of conversion to open ...
Long-term outcomes following single-portal endoscopic ...
Based on individual L-K scores, 12 ECTR patients (15 of 115 hands, 13 %) had initial improvement of at least 0.5 points at 6 months postsurgery and then had a ...
Clinical Outcomes Following Endoscopic Carpal Tunnel ...
Endoscopic carpal tunnel release is also associated with less early postoperative pain, less scar tenderness, and higher patient satisfaction. Various ECTR ...
Revision Carpal Tunnel Release Following Endoscopic ...
Although outcomes data are lacking, revision CTR has been associated with unsatisfactory results, including persistence of symptoms and ...
Open Carpal Tunnel Release – still a safe and effective ...
Forty-seven patients (51 hands) underwent carpal tunnel release and 32 patients completed the questionnaire. 88% had a significant reduction in the symptom ...
Endoscopic versus open carpal tunnel release for idiopathic ...
The results clearly indicated that ECTR significantly increased the risk of reversible postoperative nerve injury as compared with OCTR, while ...
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