PRDR Radiotherapy for Recurrent Brain Cancer (POPCORN Trial)

Palo Alto (17 mi)

Overseen byRobert Press, M.D.

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: Baptist Health South Florida

No Placebo Group

Trial Summary

What is the purpose of this trial?The purpose of this research study is to see if a specific type of radiation therapy, called "proton pulsed reduced dose rate" or "PRDR radiotherapy" has any benefits at dose levels and number of fractions thought to be acceptable in earlier research studies. The researchers want to find out what effects (good and bad) PRDR has on people with cancer in the brain called a "recurrent high-grade glioma" meaning that it grows fast, can spread quickly, and it has come back or gotten worse after being treated previously.

Eligibility Criteria

This trial is for individuals with a fast-growing, recurrent high-grade glioma (a type of brain cancer) that has returned or worsened after previous treatment. Participants should have had prior radiation therapy and be able to undergo MRI scans.

Inclusion Criteria

My brain tumor is growing or has come back.

I have received radiation therapy with a dose of at least 45 Gy.

I can do most of my daily activities by myself.

My scans show real cancer growth, not just damage from radiation, and it's been 3 months since my last radiation treatment.

My cancer has spread to new areas outside the initial treatment zone.

I have recovered from severe side effects of my last treatment, and it's been over 28 days since I received it.

My tumor was confirmed by a biopsy or surgery, and it's been over 90 days since I finished radiotherapy.

Exclusion Criteria

My cancer is present in multiple locations.

I have undergone radiotherapy at least twice.

My cancer has spread to the lining of my brain and spinal cord.

Treatment Details

The study tests 'proton pulsed reduced dose rate' (PRDR) radiotherapy on patients with recurrent brain tumors. It aims to evaluate the effects of PRDR at specific dose levels and session counts based on earlier studies.

1Treatment groups

Experimental Treatment

Group I: PRDR RadiotherapyExperimental Treatment1 Intervention