Fractional Radiofrequency vs Fractional Photothermolysis for Acne Scars

Recruiting in Palo Alto (17 mi)

Overseen ByMurad Alam, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: Northwestern University

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?The purpose of this study is to compare the effectiveness of the ePrime fractional radiofrequency system to the 1550-nm fractional photothermolysis system (Fraxel) in the ability to improve acne scar appearance.

Eligibility Criteria

This trial is for adults with specific types of acne scars on their face who are in good health and can give informed consent. It's not for those allergic to local anesthetics like lidocaine, have eyelid disfigurements, recent facial treatments (injectables or resurfacing), pregnant or breastfeeding individuals, recent isotretinoin users, or a history of abnormal scarring.

Inclusion Criteria

You have acne scars on your face that are at least 2x2 cm in size and have a specific shape, either "ice pick" or "boxcar".

Subjects are in good health.

Subjects have the willingness and the ability to understand and provide informed consent and communicate with the investigator.

+1 more

Exclusion Criteria

You are allergic to lidocaine or prilocaine.

You have an eyelid abnormality such as ectropion or a disfigurement.

You have had facial injections or resurfacing procedures within the past 6 months.

+5 more

Participant Groups

The study compares two acne scar treatments: ePrime fractional radiofrequency and Fraxel (1550-nm fractional photothermolysis). Participants will receive one treatment on each side of their face to see which improves the appearance of acne scars better.

2Treatment groups

Active Control

Group I: 1550-nm Fractional PhotothermolysisActive Control1 Intervention

Subjects will be randomly assigned to receive fractional radiofrequency treatment to either the right or left side of the face and the contralateral side will receive 1550-nm fractional photothermolysis. Subjects will receive treatments at baseline, week 4, and week 8 for a total of three treatments. Follow up visits will take place at week 16, two months following the last treatment visit.

Group II: Fractional RadiofrequencyActive Control1 Intervention