Trial Summary
What is the purpose of this trial?The purpose is to is to study if repetitive transcranial magnetic stimulation (rTMS) improves cognitive function in patients with neurodegenerative conditions which may manifest as mild to moderate cognitive impairment and, in late phase, dementia. This study also intends to investigate if the responses to rTMS intervention are either positively or negatively correlated with the initial severity of cognitive impairment.
Eligibility Criteria
This trial is for veterans aged 55 or older with mild to moderate cognitive impairment or dementia likely due to Alzheimer's, who can attend clinic visits and have stable medication doses. They must be able to consent and not have pacemakers, cochlear implants, metal in the brain, seizure risks, severe hearing issues, active CNS diseases increasing seizure risk, recent traumatic brain injury or current psychosis.Inclusion Criteria
Ability to obtain a Motor Threshold, determined during the screening process
I can read and understand the consent form and agree to participate in the study.
I am a veteran aged 55 or older with Mild Cognitive Impairment or Alzheimer's.
+2 more
Exclusion Criteria
Have an implanted device deep brain stimulation or metal in the brain
Active current suicidal intent or plan as determined by patient report or chart review
Traumatic brain injury within the last two months
+9 more
Participant Groups
The study tests whether repetitive transcranial magnetic stimulation (rTMS) improves cognitive function in patients with neurodegenerative conditions leading to dementia. It also examines if the severity of initial cognitive impairment affects rTMS response. Participants are randomly assigned to receive either rTMS or a sham (placebo-like) procedure.
2Treatment groups
Experimental Treatment
Placebo Group
Group I: RTMSExperimental Treatment1 Intervention
repetitive transcranial magnetic stimulation
Group II: shamPlacebo Group1 Intervention
sham noise to block the sound of treatment
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
VA Palo Alto Health Care System, Palo Alto, CAPalo Alto, CA
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Who Is Running the Clinical Trial?
VA Office of Research and DevelopmentLead Sponsor