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Behavioural Intervention

Brain Enhancement Training for Age-Related Cognitive Decline (BETTER Aging Trial)

N/A
Recruiting
Led By Hyun Kyu Lee, PhD
Research Sponsored by Posit Science Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 5 years and at 3 months
Awards & highlights
No Placebo-Only Group

Summary

This trial tests a brain training program that you can do online. It aims to help older adults improve their brain function by making their brains practice different tasks. The study includes both people who have done the training before and new participants.

Who is the study for?
This trial is for people aged 70 or older who speak English fluently, can see and hear well enough to use a computer, and can control a mouse. They must not have dementia as shown by the MoCA test. Those with severe visual/hearing deficits, recent cognitive training, suicidal thoughts, certain medical conditions or implants that interfere with MRI cannot join.
What is being tested?
The study tests a web-based brain training program (PACR-CT) on elders to see if it helps their cognition five years after initial training and examines the effects of an additional 10 weeks of booster training. The software poses no significant risk.
What are the potential side effects?
Since this intervention involves non-invasive computerized cognitive exercises designed for elderly individuals, there are minimal expected side effects; however, some participants may experience eye strain or mild frustration.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 5 years and at 3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 5 years and at 3 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in performance on global cognitive composite score
Secondary study objectives
Blood-based Biomarker for Alzheimer's Disease
Change in Depressive Symptoms
Change in brain function
+7 more
Other study objectives
Change in Diet
Change in Functional Abilities
Change in Life Satisfaction
+5 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Experimental TreatmentExperimental Treatment1 Intervention
Computerized plasticity-based adaptive cognitive training requiring a total maximum of 50 treatment sessions, up to 5 sessions per week, 42 minutes per session.

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Neuroplasticity-based computerized training programs, such as the PACR-CT, aim to enhance cognitive function by leveraging the brain's ability to reorganize and form new neural connections. These programs typically involve targeted cognitive exercises designed to stimulate specific brain regions, thereby improving memory, attention, and problem-solving skills. This approach is crucial for patients with Age-related Cognitive Decline as it directly addresses the underlying neural deterioration by promoting brain health and cognitive resilience, potentially slowing the progression of cognitive impairments and improving quality of life.
Committee on High-quality Alzheimer's Disease Studies (CHADS) consensus report.Observations and suggestions on antidementia drug development.

Find a Location

Who is running the clinical trial?

University of IowaOTHER
471 Previous Clinical Trials
894,481 Total Patients Enrolled
2 Trials studying Age-related Cognitive Decline
230 Patients Enrolled for Age-related Cognitive Decline
Posit Science CorporationLead Sponsor
39 Previous Clinical Trials
4,248 Total Patients Enrolled
2 Trials studying Age-related Cognitive Decline
230 Patients Enrolled for Age-related Cognitive Decline
The University of Texas at DallasOTHER
67 Previous Clinical Trials
107,927 Total Patients Enrolled
2 Trials studying Age-related Cognitive Decline
205 Patients Enrolled for Age-related Cognitive Decline
Hyun Kyu Lee, PhDPrincipal InvestigatorPosit Science Corporation
2 Previous Clinical Trials
156 Total Patients Enrolled
1 Trials studying Age-related Cognitive Decline
147 Patients Enrolled for Age-related Cognitive Decline

Media Library

PACR-CT (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05599490 — N/A
Age-related Cognitive Decline Research Study Groups: Experimental Treatment
Age-related Cognitive Decline Clinical Trial 2023: PACR-CT Highlights & Side Effects. Trial Name: NCT05599490 — N/A
PACR-CT (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05599490 — N/A
~100 spots leftby Apr 2026