[11C]PIB Imaging for Alzheimer's Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to study the buildup of a protein called amyloid in the brain, which may be linked to Alzheimer's disease. Researchers will use a special method involving [11C]PIB, an imaging agent, to measure amyloid levels in participants' brains. This trial suits those already enrolled in a study at the Alzheimer's Disease Research Center. Understanding amyloid levels could aid in developing better detection or treatment methods for Alzheimer's in the future. As an unphased trial, this study offers participants the opportunity to contribute to groundbreaking research that could lead to new ways to detect or treat Alzheimer's disease.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
Is there any evidence suggesting that [11C]PIB is likely to be safe for humans?
Research has shown that [11C]PIB has been used for many years to image the brain and examine amyloid, a protein linked to Alzheimer's disease. Studies have found it to be the best method for this type of imaging. Previous research has carefully examined the safety of [11C]PIB, particularly the effects of its radiation on the body. The results suggest that the radiation dose from [11C]PIB is safe for humans.
It is important to note that [11C]PIB is not new in medical research. It has been used in numerous studies over the years, providing extensive data indicating it is generally well-tolerated. While no treatment is without some risk, existing research supports the safety of [11C]PIB for use in imaging studies like this one.12345Why are researchers excited about this trial?
Researchers are excited about [11C]PIB because it offers a unique way to visualize and understand Alzheimer's disease early on. Most treatments for Alzheimer's focus on managing symptoms after they appear, but [11C]PIB works differently by helping to detect amyloid plaques in the brain, which are believed to be an early indicator of the disease. This imaging agent could allow doctors to identify Alzheimer's risk earlier and potentially intervene sooner, aiming to delay or prevent the onset of symptoms.
What evidence suggests that [11C]PIB is effective for measuring amyloid in the brain?
Research has shown that [11C]PIB effectively detects amyloid protein build-up in the brain, which is linked to Alzheimer's disease. Studies have found that [11C]PIB PET scans are very accurate, especially for diagnosing Alzheimer's in older adults. They excel at predicting mild cognitive impairment, which can lead to Alzheimer's. This makes them a valuable tool for understanding how Alzheimer's develops. By using [11C]PIB, researchers can clearly observe amyloid build-up, aiding in tracking the disease's progression.12678
Who Is on the Research Team?
Suzanne Craft, PhD
Principal Investigator
Wake Forest University Health Sciences
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Initial Brain Scan
Participants undergo an initial brain scan to measure amyloid levels using PET with [11C]PiB
Follow-up
Participants may undergo a follow-up brain scan two years later to measure changes in amyloid levels
What Are the Treatments Tested in This Trial?
Interventions
- [11C]PIB
Find a Clinic Near You
Who Is Running the Clinical Trial?
Wake Forest University Health Sciences
Lead Sponsor
Citations
Two decades of [11C]PiB synthesis, 2003-2023: a review - PMC
This review evaluates progress in [ 11 C]PiB radiochemistry. An introductory overview assesses how it has been applied in clinical neurologic imaging research.
Two decades of [11C]PiB synthesis, 2003-2023: a review
A review and statistical analysis found that. PiB was more sensitive in predicting MCI progression to. AD, but might have less specificity [53].
Estimation of brain amyloid accumulation using deep learning ...
A total of 1309 patients with cognitive impairment scanned with [11C]PIB PET/CT or PET/MRI were included. Two convolutional neural networks ( ...
Diagnostic Accuracy of [11C]PIB Positron Emission ...
[ 11 C]PIB PET was highly accurate in detecting cardiac involvement in the main amyloid subtypes, with 100% accuracy in AL amyloidosis.
Visual Assessment Versus Quantitative Assessment of 11 C ...
11 C-PIB PET images appear easier to read and more accurate than 18 F-FDG PET images in AD diagnosis, particularly in older subjects.
Radiation Dosimetry of β-Amyloid Tracers 11C-PiB and 18F ...
The aim of this study was to calculate the dosimetry of 11C-PiB and 18F-BAY94-9172 in healthy elderly control subjects to assess safety and suitability for ...
Fully automated dual-run manufacturing of [11C]PIB on ...
We have successfully validated a dual-run cassette-based method for manufacture of [11C]PIB under current Good Manufacturing Practice (cGMP) requirements.
Multicenter Experience with Good Manufacturing Practice ...
We present the [ 11 C]PiB production setups, experiences, and use from four Danish PET facilities and discuss the challenges and potential pitfalls of [ 11 C] ...
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