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Computerized Cognitive Tests for Early Detection of Alzheimer’s Disease

N/A

Recruiting

Research Sponsored by Neurobehavioral Systems, Inc.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Must be able to use computer mouse and touch screen.

Must be able to use computer mouse and touch screen

Must not have

History of traumatic brain injury with hospitalization and extended loss of consciousness

History of stroke or transient ischemic attack

Timeline

Screening 3 weeks

Treatment Varies

Follow Up longitudinal testing at six-month intervals

Awards & highlights

No Placebo-Only Group

Summary

This trial will help develop computerized tests to detect early signs of cognitive decline in healthy people of different ages.

Who is the study for?

This trial is for healthy individuals who can use a computer mouse and touchscreen, and speak English or Spanish as their primary language. It's not suitable for those with psychiatric disorders, stroke history, substance abuse, medical conditions affecting testing, traumatic brain injury with hospitalization and extended unconsciousness, epilepsy, depression or anxiety.

What is being tested?

The study involves performing tasks on a computer to collect standard data for new cognitive tests. These tests aim to identify early signs of age-related cognitive decline potentially leading to Alzheimer's disease in people before symptoms appear.

What are the potential side effects?

Since the intervention involves only computerized cognitive assessments without any drugs or invasive procedures involved, there are no direct physical side effects expected from participating in this trial.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can use a computer mouse and touch screen.

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I can use a computer mouse and touch screen.

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English is my primary language.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I was hospitalized for a brain injury that made me lose consciousness for a long time.

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I have had a stroke or a transient ischemic attack.

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I have a history of epilepsy.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ longitudinal testing at six-month intervals

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~longitudinal testing at six-month intervals

This trial's timeline: 3 weeks for screening, Varies for treatment, and longitudinal testing at six-month intervals for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Longitudinal normative data collection from healthy participants

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups

Experimental Treatment

Group I: Test-Retest Reliability groupExperimental Treatment1 Intervention

We will gather normative data from participants across the age range (N = 100, ages 18 to 89) for three days at enrollment, to better characterize test-retest reliability scores on Day 1 tasks.

Group II: Older participant groupExperimental Treatment1 Intervention

We will evaluate the performance of healthy older participants (N = 300, age range 60 to 89 years) for three days at enrollment and then at 6-month intervals for three years thereafter. The goal is to characterize changes in performance to aging and task experience in a group of older subjects.

Group III: Health Disparities groupExperimental Treatment1 Intervention

We will evaluate the performance of healthy older participants (N = 1200, age range 50 to 89 years) for three days at enrollment and then at 6-month intervals for three years thereafter. In the aim of better understanding health disparities in cognitive testing, this group will be divided into four cohorts: 300 African American participants; 300 Asian American participants; 300 Latino English-speaking participants; and 300 Latino Spanish-speaking participants, who will complete a Spanish translation of our computerized cognitive tests.

Group IV: CCAB vs. manual test groupExperimental Treatment1 Intervention

We will compare the performance of normal participants (N = 100, age range 18 to 89) on computerized and manually administered cognitive tasks.

0 / 6Eligibility criteria met