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Low Radiation Dose CT Techniques for Liver Disease

N/A

Waitlist Available

Led By Corey T. Jensen, MD

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Pathology proven diagnosis of colon or colorectal carcinoma

Liver metastases on most recent CT examination

Must not have

Patients cannot give informed consent

Patients cannot undergo CT examination

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 day

Awards & highlights

No Placebo-Only Group

Summary

This trial is comparing two different image processing techniques during a CT scan to see which one provides better image quality of the liver.

Who is the study for?

This trial is for adults aged 18 to 90 with a confirmed diagnosis of colon or colorectal cancer and liver metastases visible on their most recent CT scan. They must be scheduled for a standard care CT abdomen exam with IV contrast and able to give informed consent.

What is being tested?

The study is testing two different low-dose radiation techniques during a CT scan, using artificial intelligence software called DLIR to reduce image noise. The goal is to determine which method provides clearer images for detecting issues in the liver.

What are the potential side effects?

Since this trial involves imaging techniques rather than drugs, side effects are minimal but may include exposure to lower levels of radiation compared to standard CT scans.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with colon or colorectal cancer.

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My latest CT scan shows cancer has spread to my liver.

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I am between 18 and 90 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am unable to understand and agree to the study's procedures and risks.

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I cannot have a CT scan.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 day

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 day

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Metastasis Detection Accuracy

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Group I: Deep Learning Image Reconstruction (DLIR)Experimental Treatment1 Intervention

DLIR is available in both single (SE) and dual/multi energy (DE) CT scanning modes. DLIR SECT and DLIR DECT reconstructions have yet to be compared.

Group II: Computed tomography Scan - 70% Dose ReductionExperimental Treatment1 Intervention

Participants undergo routine standard of care CT examination for colon carcinoma restaging, then have an additional scan of the liver at 70% dose reduction.

Group III: Computed Tomography Scan - 50% Dose ReductionExperimental Treatment1 Intervention

Participants undergo routine standard of care CT examination for colon carcinoma restaging, then have an additional scan of the liver at 50% dose reduction.

0 / 5Eligibility criteria met