Ketone Supplement for Colorectal Cancer Prevention
(BHB-CRC Trial)

Recruiting in Palo Alto (17 mi)

Overseen byBryson W Katona, MD, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Abramson Cancer Center of the University of Pennsylvania

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial is testing a BHB supplement, which is a type of ketone used for energy, in patients having a colonoscopy or flexible sigmoidoscopy. The goal is to see if the supplement is safe and if it changes the cells in the colon.

Eligibility Criteria

This trial is for adults over 18 who can consent and are scheduled for a standard colonoscopy or flexible sigmoidoscopy. It's not suitable for those with diabetes on medication, severe kidney disease, active cancer treatment, pregnancy, incarceration, under 18s, history of bowel diseases or recent fasting diets.

Inclusion Criteria

Can provide informed consent

I am scheduled for a colonoscopy or sigmoidoscopy as part of my routine care.

I am 18 years old or older.

Exclusion Criteria

I have a history of inflammatory bowel disease.

I have diabetes and am currently receiving treatment for it.

I am currently undergoing treatment for my cancer.

+5 more

Participant Groups

The study tests if taking β-hydroxybutyrate (BHB) supplement is feasible for people getting routine colon checks. BHB is thought to help in preventing colorectal cancer.

1Treatment groups

Experimental Treatment

Group I: BHB supplementationExperimental Treatment1 Intervention

Study participants will be taking 35mL of HVMN Ketone-IQ by mouth three times daily, with each dose containing 10 grams of R-1,3-Butanediol, for a total of 4 weeks.