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CAPTIVA-MRI Group for Stroke (CAPTIVA-MRI Trial)

N/A
Recruiting
Led By Sepideh Amin-Hanjani, MD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

Summary

CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.

Eligible Conditions
  • Stroke
  • Intracranial Atherosclerotic Stenosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Establish ICAS hemodynamic and plaque MRI biomarkers as reliable predictors of recurrent ischemic stroke in the vascular territory of the index stroke.

Trial Design

1Treatment groups
Experimental Treatment
Group I: CAPTIVA-MRI GroupExperimental Treatment1 Intervention
CAPTIVA patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.

Find a Location

Who is running the clinical trial?

National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,362 Previous Clinical Trials
650,450 Total Patients Enrolled
173 Trials studying Stroke
80,870 Patients Enrolled for Stroke
Yale UniversityLead Sponsor
1,907 Previous Clinical Trials
3,018,749 Total Patients Enrolled
17 Trials studying Stroke
16,234 Patients Enrolled for Stroke
Sepideh Amin-Hanjani, MDPrincipal InvestigatorUniversity Hospitals
2 Previous Clinical Trials
241 Total Patients Enrolled
2 Trials studying Stroke
241 Patients Enrolled for Stroke
~200 spots leftby Mar 2029
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